Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury.

Gjurasin M, Miklic P, Zupancic B, Perovic D, Zarkovic K, Brcic L, Kolenc D, Radic B, Seiwerth S, Sikiric P

Regulatory peptides10 Nov 2009Cited by 32 (Europe PMC)

PMID19903499DOI10.1016/j.regpep.2009.11.005PepBankPUB-19903499

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 markedly improved nerve healing.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 clearly improved nerve healing.
Peptide
BPC-157
Outcome
IncreaseSciatic nerve healing (overall)
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
Thus, BPC 157 markedly improved rat sciatic nerve healing.
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 gave faster axonal regeneration on histomorphometry.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 led to faster nerve fibre regrowth under the microscope.
Peptide
BPC-157
Outcome
IncreaseAxonal regeneration (histomorphometric)
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
BPC 157-rats exhibited faster axonal regeneration
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 increased the density and size of regenerative fibers.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave denser and larger regrowing nerve fibres.
Peptide
BPC-157
Outcome
IncreaseDensity and size of regenerative fibers
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
increased density and size of regenerative fibers
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 gave a higher proportion of neural versus connective tissue.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave a larger share of nerve tissue compared with scar-like tissue.
Peptide
BPC-157
Outcome
IncreaseProportion of neural versus connective tissue
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
higher proportion of neural vs. connective tissue
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 increased the diameter of myelinated fibers in all fascicles.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave thicker insulated nerve fibres.
Peptide
BPC-157
Outcome
IncreaseDiameter of myelinated fibers
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
increased diameter of myelinated fibers
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 increased the thickness of the myelin sheath in all fascicles.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave a thicker insulating myelin layer on nerve fibres.
Peptide
BPC-157
Outcome
IncreaseThickness of myelin sheath
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
thickness of myelin sheet
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 increased the number of myelinated fibers per area in all fascicles.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave more insulated nerve fibres per area.
Peptide
BPC-157
Outcome
IncreaseNumber of myelinated fibers per area
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
number of myelinated fibers per area
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349907
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 increased myelinated fibers as a percentage of the nerve transected area in all fascicles.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave a larger share of the nerve area filled with insulated fibres.
Peptide
BPC-157
Outcome
IncreaseMyelinated fibers as percentage of nerve transected area
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
myelinated fibers as a percentage of the nerve transected area
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349908
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 increased the presentation of blood vessels.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave more blood vessels in the nerve.
Peptide
BPC-157
Outcome
IncreaseBlood vessel presentation in the nerve
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
the increased blood vessels presentation
1 context sentence(design, population, supporting numbers)
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349909
10AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 increased motor action potentials on electrophysiology.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 gave stronger nerve signals to the muscle.
Peptide
BPC-157
Outcome
IncreaseMotor action potentials (EMG)
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
electrophysiologically (increased motor action potentials
2 context sentences(design, population, supporting numbers)
Summary · context
Improvement was shown clinically (autotomy), microscopically/morphometrically and functionally (EMG, one or two months post-injury, walking recovery (sciatic functional index (SFI)) at weekly intervals).
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349910
11AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 improved the sciatic functional index.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 improved walking recovery.
Peptide
BPC-157
Outcome
IncreaseWalking recovery (sciatic functional index)
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
functionally (improved SFI)
2 context sentences(design, population, supporting numbers)
Summary · context
Improvement was shown clinically (autotomy), microscopically/morphometrically and functionally (EMG, one or two months post-injury, walking recovery (sciatic functional index (SFI)) at weekly intervals).
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349911
12AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected sciatic nerve, BPC‑157 treatment left the autotomy absent.
In plain wordsIn rats with a cut sciatic nerve, BPC‑157 treated rats did not bite or injure the affected limb.
Peptide
BPC-157
Outcome
DecreaseAutotomy
Study
ratn: not reported in source
Transected sciatic nerve (anastomosis, or nerve tubing after 7 mm segment resected)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg/kg, 10 ng/kg · intraperitoneal, intragastric, local at the anastomosis site, or into the nerve tubeAs given in this study (rat).
Source sentences
Summary
the autotomy absent.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically (autotomy), microscopically/morphometrically and functionally (EMG, one or two months post-injury, walking recovery (sciatic functional index (SFI)) at weekly intervals).
Summary · context
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm ner…
Report a problemFND-1990349912

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.