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Study · Not a test of the peptide alone · 2009

6 results

Downregulation of thymosin beta4 in neural progenitor grafts promotes spinal cord regeneration.

Mollinari C, Ricci-Vitiani L, Pieri M, Lucantoni C, Rinaldi AM, Racaniello M, De Maria R, Zona C, Pallini R, Merlo D, Garaci E

Journal of cell science27 Oct 2009Cited by 31 (Europe PMC)

PMID19861493 (opens in a new tab)DOI10.1242/jcs.056895 (opens in a new tab)PepBankPUB-19861493
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In a mouse model of spinal cord injury, transplanted Tbeta4-antisense NPCs promoted significantly greater functional recovery.

    In plain wordsIn mice with spinal cord injury, grafts of cells with lowered Tbeta4 improved recovery of movement.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseFunctional recovery after spinal cord injury
    Study

    mousen: not reported in source

    mouse model of spinal cord injury
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Importantly, when the Tbeta4-antisense-transduced NPCs were transplanted in vivo into a mouse model of spinal cord injury, they promoted a significantly greater functional recovery.
    1 context sentence
    Summary · context
    Here, we studied the effects of the downregulation of Tbeta4 expression on growth and differentiation of murine neural progenitor cells (NPCs), using an antisense lentiviral vector.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, locomotory recovery correlated with increased L1 expression by grafted Tbeta4-antisense NPCs.

    In plain wordsIn mice with spinal cord injury, better movement recovery was linked to more L1 protein in the grafted cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseL1 expression by grafted NPCs
    Study

    mousen: not reported in source

    mouse model of spinal cord injury
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Locomotory recovery correlated with increased expression of the regeneration-promoting cell adhesion molecule L1 by the grafted Tbeta4-antisense-transduced NPCs.
    1 context sentence
    Summary · context
    Here, we studied the effects of the downregulation of Tbeta4 expression on growth and differentiation of murine neural progenitor cells (NPCs), using an antisense lentiviral vector.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, Tbeta4-antisense NPC grafts increased the number of regenerating axons and sprouting of serotonergic fibers near the grafted cells.

    In plain wordsIn mice with spinal cord injury, grafts of cells with lowered Tbeta4 led to more regrowing nerve fibers near the graft.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRegenerating axons and serotonergic fiber sprouting
    Study

    mousen: not reported in source

    mouse model of spinal cord injury
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    This resulted in an increased number of regenerating axons and in sprouting of serotonergic fibers surrounding and contacting the Tbeta4-antisense-transduced NPCs grafted into the lesion site.
    1 context sentence
    Summary · context
    Here, we studied the effects of the downregulation of Tbeta4 expression on growth and differentiation of murine neural progenitor cells (NPCs), using an antisense lentiviral vector.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In murine neural progenitor cells in differentiation medium, Tbeta4 antisense knockdown gave twice the number of neurons.

    In plain wordsIn cells, lowering Tbeta4 gave twice the number of neurons.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNeuron number from NPCs in differentiation medium
    Study

    mousen: not reported in source

    murine neural progenitor cells
    Comparator
    Control NPCs
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In differentiation-promoting medium, we found twice the number of neurons derived from the Tbeta4-antisense-transduced NPCs
    1 context sentence
    Summary · context
    Here, we studied the effects of the downregulation of Tbeta4 expression on growth and differentiation of murine neural progenitor cells (NPCs), using an antisense lentiviral vector.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In murine neural progenitor cells, Tbeta4 antisense knockdown enhanced neurite outgrowth.

    In plain wordsIn cells, lowering Tbeta4 increased the growth of nerve cell extensions.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNeurite outgrowth
    Study

    mousen: not reported in source

    murine neural progenitor cells
    Comparator
    Control NPCs
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    which showed enhanced neurite outgrowth
    1 context sentence
    Summary · context
    Here, we studied the effects of the downregulation of Tbeta4 expression on growth and differentiation of murine neural progenitor cells (NPCs), using an antisense lentiviral vector.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  6. 06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In murine neural progenitor cells, Tbeta4 antisense knockdown increased expression of the N-cadherin-beta-catenin adhesion complex and ERK activation.

    In plain wordsIn cells, lowering Tbeta4 raised an adhesion protein complex and the activity of ERK.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseN-cadherin-beta-catenin and ERK activation
    Study

    mousen: not reported in source

    murine neural progenitor cells
    Comparator
    Control NPCs
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    accompanied by increased expression of the adhesion complex N-cadherin-beta-catenin and increased ERK activation
    1 context sentence
    Summary · context
    Here, we studied the effects of the downregulation of Tbeta4 expression on growth and differentiation of murine neural progenitor cells (NPCs), using an antisense lentiviral vector.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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