In cells overexpressing the human MC4 receptor, Eu(III)-DOTA-labeled NDP-alpha-MSH bound with an affinity similar to its DTPA analogue.
In plain wordsIn lab tests, the labeled NDP-alpha-MSH peptide bound to MC4 receptor cells about as tightly as its DTPA version.
- Peptide
- Melanotan I (afamelanotide)
- Outcome
- No significant changeBinding affinity of Eu(III)-DOTA-labeled NDP-alpha-MSH to hMC4 receptor cells
- Study
humann: not reported in source
Cells overexpressing the human melanocortin-4 receptor- Comparator
- Eu(III)-DTPA analogue
- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
Binding data indicate that the Eu(III)-DOTA-linked peptide bound to these cells with an affinity similar to its DTPA analogue.
1 context sentence(design, population, supporting numbers)
[Nle(4),d-Phe(7)]-alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) labeled with Eu(III)-DOTA was synthesized, and the binding affinity to cells overexpressing the human melanocortin-4 (hMC4) receptor was evaluated using the modified protocol.
In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).