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Study · In vitro (cells) · 2009

6 results

[Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro study)].

Garmanchuk LV, Perepelitsyna EM, Sidorenko Mv, Makarenko AN, Kul'chikov AE

Eksperimental'naia i klinicheskaia farmakologiia1 Jul 2009Cited by 2 (Europe PMC)

PMID19803367 (opens in a new tab)PepBankPUB-19803367
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In MT-4 cells, Cerebrolysin showed cytoprotective properties and favored T-lymphocyte survival.

    In plain wordsIn cells, Cerebrolysin favored T-lymphocyte survival.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseT-lymphocyte survival
    Study

    n: not reported in source

    MT-4 T-lymphocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that cerebrolysin exhibits cytoprotective properties with respect to both T- and B-lymphocytes and favors the survival of immunocompetent cells.
    1 context sentence
    Summary · context
    Effects of the nootropic neuropeptide drugs cerebrolysin (Ebewe, Austria) and cortexin (Geterofarm, Russia) on the immunocompetent cells (T-lymphocytes of the MT-4 cell line and B-lymphocytes of the Raji cell line) were studied in vitro.
  2. 02LabIn vitro (cells)Efficacy outcome

    In Raji cells, Cerebrolysin showed cytoprotective properties and favored B-lymphocyte survival.

    In plain wordsIn cells, Cerebrolysin favored B-lymphocyte survival.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseB-lymphocyte survival
    Study

    n: not reported in source

    Raji B-lymphocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that cerebrolysin exhibits cytoprotective properties with respect to both T- and B-lymphocytes and favors the survival of immunocompetent cells.
    1 context sentence
    Summary · context
    Effects of the nootropic neuropeptide drugs cerebrolysin (Ebewe, Austria) and cortexin (Geterofarm, Russia) on the immunocompetent cells (T-lymphocytes of the MT-4 cell line and B-lymphocytes of the Raji cell line) were studied in vitro.
  3. 03LabIn vitro (cells)Efficacy outcome

    In Raji cells, Cerebrolysin produced a proliferative effect on B-lymphocytes at certain concentrations.

    In plain wordsIn cells, Cerebrolysin increased B-lymphocyte proliferation at certain concentrations.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseB-lymphocyte proliferation
    Study

    n: not reported in source

    Raji B-lymphocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, cerebrolysin in certain concentrations produces a proliferative effect on B-lymphocytes, thus stimulating the formation of immune memory B cells.
    1 context sentence
    Summary · context
    Effects of the nootropic neuropeptide drugs cerebrolysin (Ebewe, Austria) and cortexin (Geterofarm, Russia) on the immunocompetent cells (T-lymphocytes of the MT-4 cell line and B-lymphocytes of the Raji cell line) were studied in vitro.
  4. 04LabIn vitro (cells)Safety outcome

    In cultured MT-4 T-lymphocytes, Cortexin produced cytotoxic effects at certain concentrations.

    In plain wordsIn cells, Cortexin had toxic effects on T-lymphocytes at certain concentrations.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseT-lymphocyte cytotoxicity
    Study

    n: not reported in source

    MT-4 T-lymphocytes
    Outcome group
    Adverse events · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, cortexin in certain concentrations produces a cytotoxic and antiproliferative action on T-lymphocytes.
    2 context sentences
    Summary · context
    Effects of the nootropic neuropeptide drugs cerebrolysin (Ebewe, Austria) and cortexin (Geterofarm, Russia) on the immunocompetent cells (T-lymphocytes of the MT-4 cell line and B-lymphocytes of the Raji cell line) were studied in vitro.
    Summary · context
    The cell viability was evaluated using the MTT test by counting living and dead cells upon incubation under various conditions with a vital stain (Trypan Blue).
  5. 05LabIn vitro (cells)Activity measurement

    In cultured MT-4 T-lymphocytes, Cortexin produced antiproliferative effects at certain concentrations.

    In plain wordsIn cells, Cortexin inhibited T-lymphocyte multiplication at certain concentrations.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseT-lymphocyte proliferation
    Study

    n: not reported in source

    MT-4 T-lymphocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, cortexin in certain concentrations produces a cytotoxic and antiproliferative action on T-lymphocytes.
    2 context sentences
    Summary · context
    Effects of the nootropic neuropeptide drugs cerebrolysin (Ebewe, Austria) and cortexin (Geterofarm, Russia) on the immunocompetent cells (T-lymphocytes of the MT-4 cell line and B-lymphocytes of the Raji cell line) were studied in vitro.
    Summary · context
    The cell viability was evaluated using the MTT test by counting living and dead cells upon incubation under various conditions with a vital stain (Trypan Blue).

Studies that did not test the peptide alone1

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

  1. 06LabNot a test of Cortexin (cortical polypeptide complex) aloneIn vitro (cells)Mechanism

    In cultured lymphocytes, both drugs' effects depended on concentration, exposure duration and, most strongly, cell type.

    In plain wordsIn cells, both drugs' effects depended on concentration, exposure time and, most strongly, cell type.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedDependence of cellular effects on exposure conditions and cell type
    Study

    n: not reported in source

    MT-4 T-lymphocytes and Raji B-lymphocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    The parameters of influence for both drugs depend on their concentration in the cell incubation medium, the duration of action, and (most significantly) the cell type.
    1 context sentence
    Summary · context
    Effects of the nootropic neuropeptide drugs cerebrolysin (Ebewe, Austria) and cortexin (Geterofarm, Russia) on the immunocompetent cells (T-lymphocytes of the MT-4 cell line and B-lymphocytes of the Raji cell line) were studied in vitro.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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