In young mice, hexarelin increased the number of BrdU-positive proliferating cells in the hippocampal granule cell layer by approximately 50% compared with controls.
In plain wordsIn young mice, hexarelin raised the number of dividing cells in a memory-related brain area by about 50% compared with controls.
- Peptide
- Hexarelin
- Outcome
- IncreaseBrdU-positive cells in the granule cell layer of the dentate gyrus
- Study
mousen: not reported in source
10-day-old male mice with 6Gy cranial irradiation and sham controls- Comparator
- Controls
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 100 µg/kg/day · 28 daysAs given in this study (mouse).
Measurements
- BrdU-positive cells increase
- ≈ 50%
- hexarelin versus controls
Source sentences
Our results show that hexarelin significantly increased the number of BrdU-positive cells in the granule cell layer by approximately 50% compared to controls.
2 context sentences(design, population, supporting numbers)
In the present study, 10-day-old male mice received 6Gy cranial IR.
We treated one group of irradiated and one sham group with hexarelin (100microg/kg/day) for 28days and used immunohistochemical labeling of bromo-deoxy uridine (BrdU) and phospho-histone H3 of the granular cell layer of the DG to evaluate proliferation and cell survival after IR at postnatal day ten.