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Study · Animal study (in vivo) · cattle · 2009

7 results

Characteristics of the stimulatory effect of kisspeptin-10 on the secretion of luteinizing hormone, follicle-stimulating hormone and growth hormone in prepubertal male and female cattle.

Ezzat Ahmed A, Saito H, Sawada T, Yaegashi T, Yamashita T, Hirata T, Sawai K, Hashizume T

The Journal of reproduction and development29 Sept 2009Cited by 42 (Europe PMC)

PMID19789422 (opens in a new tab)DOI10.1262/jrd.20255 (opens in a new tab)PepBankPUB-19789422
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal male and female calves, a single intravenous injection of kisspeptin‑10 significantly stimulated LH release.

    In plain wordsIn young male and female calves, a single injection of kisspeptin‑10 into a vein raised LH release.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after intravenous injection
    Study

    cattlen = 10

    Prepubertal Japanese Black calves
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 μg/kg body weight · intravenous · single injectionAs given in this study (cattle).

    Source sentences

    Summary
    A single intravenous (iv) injection of Kp10 (5 microg/kg body weight (b.w.): 3.85 nmol/ kg b.w.) significantly stimulated the release of LH and FSH in male and female calves (P<0.05).
    1 context sentence
    Summary · context
    The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal male and female calves, a single intravenous injection of kisspeptin‑10 significantly stimulated FSH release.

    In plain wordsIn young male and female calves, a single injection of kisspeptin‑10 into a vein raised FSH release.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFSH release after intravenous injection
    Study

    cattlen = 10

    Prepubertal Japanese Black calves
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 μg/kg body weight · intravenous · single injectionAs given in this study (cattle).

    Source sentences

    Summary
    A single intravenous (iv) injection of Kp10 (5 microg/kg body weight (b.w.): 3.85 nmol/ kg b.w.) significantly stimulated the release of LH and FSH in male and female calves (P<0.05).
    1 context sentence
    Summary · context
    The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal male and female calves, kisspeptin‑10 injection did not alter basal plasma growth hormone.

    In plain wordsIn young male and female calves, kisspeptin‑10 did not change blood growth hormone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeBasal plasma GH concentration
    Study

    cattlen = 10

    Prepubertal Japanese Black calves
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 μg/kg body weight · intravenous · single injectionAs given in this study (cattle).

    Source sentences

    Summary
    The injection of Kp10 did not alter the basal plasma concentration of GH in male or female calves.
    1 context sentence
    Summary · context
    The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    After intravenous kisspeptin‑10, the 120-min LH area under the curve was significantly greater in male than in female calves.

    In plain wordsAfter kisspeptin‑10 into a vein, the LH rise in young male calves was greater than in young female calves.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH AUC over 120 min, males versus females
    Study

    cattlen = 10

    Prepubertal Japanese Black calves
    Comparator
    Female calves
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 μg/kg body weight · intravenous · single injectionAs given in this study (cattle).

    Source sentences

    Summary
    The area under the curve (AUC) of both LH and FSH for a 120-min period after the iv injection of Kp10 was significantly greater in the males than females (P<0.05).
    1 context sentence
    Summary · context
    The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    After intravenous kisspeptin‑10, the 120-min FSH area under the curve was significantly greater in male than in female calves.

    In plain wordsAfter kisspeptin‑10 into a vein, the FSH rise in young male calves was greater than in young female calves.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFSH AUC over 120 min, males versus females
    Study

    cattlen = 10

    Prepubertal Japanese Black calves
    Comparator
    Female calves
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 μg/kg body weight · intravenous · single injectionAs given in this study (cattle).

    Source sentences

    Summary
    The area under the curve (AUC) of both LH and FSH for a 120-min period after the iv injection of Kp10 was significantly greater in the males than females (P<0.05).
    1 context sentence
    Summary · context
    The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal male calves, an intramuscular injection of kisspeptin‑10 significantly stimulated LH release, but the response was smaller than after the intravenous injection.

    In plain wordsIn young male calves, kisspeptin‑10 injected into muscle raised LH release, but less than when injected into a vein.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after intramuscular injection
    Study

    cattlen = 5

    Prepubertal Japanese Black calves
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 μg/kg body weight · intramuscular · single injectionAs given in this study (cattle).

    Source sentences

    Summary
    A single intramuscular injection of Kp10 (5 microg/kg b.w.) also significantly stimulated the release of LH and FSH in male calves (P<0.05), though the response was smaller than that to the iv injection.
    1 context sentence
    Summary · context
    The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal male calves, an intramuscular injection of kisspeptin‑10 significantly stimulated FSH release, but the response was smaller than after the intravenous injection.

    In plain wordsIn young male calves, kisspeptin‑10 injected into muscle raised FSH release, but less than when injected into a vein.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFSH release after intramuscular injection
    Study

    cattlen = 5

    Prepubertal Japanese Black calves
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    5 μg/kg body weight · intramuscular · single injectionAs given in this study (cattle).

    Source sentences

    Summary
    A single intramuscular injection of Kp10 (5 microg/kg b.w.) also significantly stimulated the release of LH and FSH in male calves (P<0.05), though the response was smaller than that to the iv injection.
    1 context sentence
    Summary · context
    The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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