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Study · Animal study (in vivo) · mouse · 2009

7 results

Neurological functional recovery after thymosin beta4 treatment in mice with experimental auto encephalomyelitis.

Zhang J, Zhang ZG, Morris D, Li Y, Roberts C, Elias SB, Chopp M

Neuroscience25 Sept 2009Cited by 69 (Europe PMC)

PMID19782721 (opens in a new tab)PMCIDPMC2784109 (opens in a new tab)DOI10.1016/j.neuroscience.2009.09.054 (opens in a new tab)PepBankPUB-19782721
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental autoimmune encephalomyelitis, Tbeta4 treatment improved functional recovery.

    In plain wordsIn mice with a model of multiple sclerosis, Tbeta4 improved recovery of nerve function.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNeurological functional recovery after EAE
    Study

    mousen = 21

    SJL/J mice with EAE
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · five doses, every 3 daysAs given in this study (mouse).

    Source sentences

    Summary
    Tbeta4 treatment improved functional recovery after EAE.
    2 context sentences
    Summary · context
    To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
    Summary · context
    EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, inflammatory infiltrates were significantly reduced with Tbeta4 compared with saline.

    In plain wordsIn mice with a model of multiple sclerosis, Tbeta4 reduced inflammatory cell build-up compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseInflammatory infiltrates
    Study

    mousen = 21

    SJL/J mice with EAE
    Comparator
    Saline
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    6 mg/kg · five doses, every 3 daysAs given in this study (mouse).

    Measurements

    Inflammatory infiltrates
    3.6 /slide
    Tbeta4
    Inflammatory infiltrates
    5 /slide
    saline

    Source sentences

    Summary
    Inflammatory infiltrates were significantly reduced in the Tbeta4 treatment group compared to the saline groups (3.6+/-0.3/slide vs 5+/-0.5/slide, P<0.05).
    2 context sentences
    Summary · context
    To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
    Summary · context
    EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, NG2+ oligodendrocyte progenitor cells in the subventricular zone were significantly increased with Tbeta4 compared with saline.

    In plain wordsIn mice with a model of multiple sclerosis, Tbeta4 increased oligodendrocyte progenitor cells in one brain region compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNG2+ OPCs in subventricular zone
    Study

    mousen = 21

    SJL/J mice with EAE
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · five doses, every 3 daysAs given in this study (mouse).

    Measurements

    NG2+ OPCs
    447.7 /mm(2)
    Tbeta4, SVZ
    NG2+ OPCs
    195.2 /mm(2)
    saline, SVZ

    Source sentences

    Summary
    NG2(+) OPCs (447.7+/-41.9 vs 195.2+/-31/mm(2) in subventricular zone (SVZ)
    3 context sentences
    Summary · context
    were significantly increased in the Tbeta4 treated mice compared to those of saline controls (P<0.05).
    Summary · context
    To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
    Summary · context
    EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, NG2+ oligodendrocyte progenitor cells in white matter were significantly increased with Tbeta4 compared with saline.

    In plain wordsIn mice with a model of multiple sclerosis, Tbeta4 increased oligodendrocyte progenitor cells in white matter compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNG2+ OPCs in white matter
    Study

    mousen = 21

    SJL/J mice with EAE
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · five doses, every 3 daysAs given in this study (mouse).

    Measurements

    NG2+ OPCs
    75.1 /mm(2)
    Tbeta4, white matter
    NG2+ OPCs
    41.7 /mm(2)
    saline, white matter

    Source sentences

    Summary
    75.1+/-4.7 vs 41.7+/-3.2/mm(2) in white matter), CNPase(+) mature oligodendrocytes (267.5+/-10.3 vs 141.4+/-22.9/mm(2)), BrdU(+) with NG2(+) OPCs (32.9+/-3.7 vs 17.9+/-3.6/mm(2)), BrdU(+) with CNPase(+) mature oligodendrocytes (18.2+/-1.7 vs 10.7+/-2.2/mm(2)) were significantly increased in the Tbet…
    3 context sentences
    Summary · context
    were significantly increased in the Tbeta4 treated mice compared to those of saline controls (P<0.05).
    Summary · context
    To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
    Summary · context
    EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, CNPase+ mature oligodendrocytes were significantly increased with Tbeta4 compared with saline.

    In plain wordsIn mice with a model of multiple sclerosis, Tbeta4 increased mature myelin-making cells compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCNPase+ mature oligodendrocytes
    Study

    mousen = 21

    SJL/J mice with EAE
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · five doses, every 3 daysAs given in this study (mouse).

    Measurements

    CNPase+ mature oligodendrocytes
    267.5 /mm(2)
    Tbeta4
    CNPase+ mature oligodendrocytes
    141.4 /mm(2)
    saline

    Source sentences

    Summary
    CNPase(+) mature oligodendrocytes (267.5+/-10.3 vs 141.4+/-22.9/mm(2))
    3 context sentences
    Summary · context
    were significantly increased in the Tbeta4 treated mice compared to those of saline controls (P<0.05).
    Summary · context
    To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
    Summary · context
    EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, BrdU+ proliferating NG2+ progenitor cells were significantly increased with Tbeta4 compared with saline.

    In plain wordsIn mice with a model of multiple sclerosis, Tbeta4 increased dividing progenitor cells compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseBrdU+ NG2+ proliferating OPCs
    Study

    mousen = 21

    SJL/J mice with EAE
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · five doses, every 3 daysAs given in this study (mouse).

    Measurements

    BrdU+ NG2+ OPCs
    32.9 /mm(2)
    Tbeta4
    BrdU+ NG2+ OPCs
    17.9 /mm(2)
    saline

    Source sentences

    Summary
    BrdU(+) with NG2(+) OPCs (32.9+/-3.7 vs 17.9+/-3.6/mm(2))
    3 context sentences
    Summary · context
    were significantly increased in the Tbeta4 treated mice compared to those of saline controls (P<0.05).
    Summary · context
    To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
    Summary · context
    EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, BrdU+ CNPase+ mature oligodendrocytes were significantly increased with Tbeta4 compared with saline.

    In plain wordsIn mice with a model of multiple sclerosis, Tbeta4 increased new mature myelin-making cells compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseBrdU+ CNPase+ proliferating mature oligodendrocytes
    Study

    mousen = 21

    SJL/J mice with EAE
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · five doses, every 3 daysAs given in this study (mouse).

    Measurements

    BrdU+ CNPase+ oligodendrocytes
    18.2 /mm(2)
    Tbeta4
    BrdU+ CNPase+ oligodendrocytes
    10.7 /mm(2)
    saline

    Source sentences

    Summary
    BrdU(+) with CNPase(+) mature oligodendrocytes (18.2+/-1.7 vs 10.7+/-2.2/mm(2))
    3 context sentences
    Summary · context
    were significantly increased in the Tbeta4 treated mice compared to those of saline controls (P<0.05).
    Summary · context
    To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
    Summary · context
    EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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