[Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo.

Guo F, Jing W, Ma CG, Wu MN, Zhang JF, Li XY, Qi JS

Synapse (New York, N.Y.)1 Jan 2010Cited by 21 (Europe PMC)

PMID19768812DOI10.1002/syn.20707PepBankPUB-19768812

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intracerebroventricular HNG prevented the suppression of hippocampal long-term potentiation induced by Abeta fragments in a dose-dependent manner.
In plain wordsIn rats, a humanin derivative injected into the brain protected a memory-related brain signal from amyloid beta, with larger doses working better.
Peptide
Humanin
Outcome
IncreasePrevention of Abeta-induced LTP suppression
Study
ratn: not reported in source
Rat hippocampal CA1 region in vivo, LTP suppressed by Abeta fragments
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
while HNG effectively prevented the suppression of LTP induced by Abeta fragments in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study examined the effects of intracerebroventricular (i.c.v.) injection of HNG on amyloid beta (Abeta), a main constituent of senile plaques in the AD brain, induced suppression of long-term potentiation (LTP) in the rat hippocampal CA1 region in vivo and investigated the possible mecha…
Report a problemFND-1976881201

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

02AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism
In rats pretreated with the tyrosine kinase inhibitor genistein, the protective action of HNG on LTP was nearly completely abolished.
In plain wordsIn rats, blocking tyrosine kinase with genistein almost fully removed the protection that a humanin derivative gave to a memory-related brain signal.
Peptide
Humanin
Outcome
DecreaseHNG protection of LTP after genistein pretreatment
Study
ratn: not reported in source
Rat hippocampal CA1 region in vivo, LTP suppressed by Abeta fragments
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
After pretreatment with Genistein, a tyrosine kinase inhibitor, the protective action of HNG on LTP was nearly completely abolished.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study examined the effects of intracerebroventricular (i.c.v.) injection of HNG on amyloid beta (Abeta), a main constituent of senile plaques in the AD brain, induced suppression of long-term potentiation (LTP) in the rat hippocampal CA1 region in vivo and investigated the possible mecha…
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-1976881202

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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