Protective role of carnosine in mice with cadmium-induced acute hepatotoxicity.

Fouad AA, Qureshi HA, Yacoubi MT, Al-Melhim WN

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association11 Sept 2009Cited by 33 (Europe PMC)

PMID19748544DOI10.1016/j.fct.2009.09.009PepBankPUB-19748544

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine significantly decreased cadmium-induced elevations in serum aminotransferases.
In plain wordsIn mice, carnosine reduced serum aminotransferases compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
DecreaseSerum aminotransferases
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Liver fat and liver function · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Carnosine significantly decreased the cadmium-induced elevations in serum aminotransferases.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854401
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine suppressed liver lipid peroxidation induced by cadmium.
In plain wordsIn mice, carnosine reduced liver lipid peroxidation compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
DecreaseLiver lipid peroxidation
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Oxidative stress · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Carnosine suppressed lipid peroxidation and restored the deficits in the antioxidant defense mechanisms (reduced glutathione level, and catalase and superoxide dismutase activities) in liver tissue resulted from cadmium administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854402
03AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine restored reduced glutathione levels depleted by cadmium in liver tissue.
In plain wordsIn mice, carnosine restored liver glutathione levels compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
IncreaseReduced glutathione
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Oxidative stress · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Carnosine suppressed lipid peroxidation and restored the deficits in the antioxidant defense mechanisms (reduced glutathione level, and catalase and superoxide dismutase activities) in liver tissue resulted from cadmium administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854403
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine restored liver catalase activity depleted by cadmium.
In plain wordsIn mice, carnosine restored liver catalase activity compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
IncreaseCatalase activity
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Oxidative stress · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Carnosine suppressed lipid peroxidation and restored the deficits in the antioxidant defense mechanisms (reduced glutathione level, and catalase and superoxide dismutase activities) in liver tissue resulted from cadmium administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854404
05AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine restored liver superoxide dismutase activity depleted by cadmium.
In plain wordsIn mice, carnosine restored liver superoxide dismutase activity compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
IncreaseSuperoxide dismutase activity
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Oxidative stress · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Carnosine suppressed lipid peroxidation and restored the deficits in the antioxidant defense mechanisms (reduced glutathione level, and catalase and superoxide dismutase activities) in liver tissue resulted from cadmium administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854405
06AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine significantly attenuated cadmium-induced reductions in hepatic nitric oxide levels.
In plain wordsIn mice, carnosine reduced the loss of liver nitric oxide compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
IncreaseHepatic nitric oxide
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Liver fat and liver function · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Also, the reductions in hepatic nitric oxide and zinc ion levels, and the increases in hepatic cadmium ion concentration, and myeloperoxidase and caspase-3 activities following cadmium exposure were significantly attenuated by carnosine treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854406
07AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine significantly attenuated cadmium-induced reductions in hepatic zinc ion levels.
In plain wordsIn mice, carnosine reduced the loss of liver zinc ions compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
IncreaseHepatic zinc ions
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Liver fat and liver function · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Also, the reductions in hepatic nitric oxide and zinc ion levels, and the increases in hepatic cadmium ion concentration, and myeloperoxidase and caspase-3 activities following cadmium exposure were significantly attenuated by carnosine treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854407
08AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine significantly attenuated increases in hepatic cadmium ion concentration after cadmium exposure.
In plain wordsIn mice, carnosine reduced liver cadmium accumulation compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
DecreaseHepatic cadmium ions
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Liver fat and liver function · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Also, the reductions in hepatic nitric oxide and zinc ion levels, and the increases in hepatic cadmium ion concentration, and myeloperoxidase and caspase-3 activities following cadmium exposure were significantly attenuated by carnosine treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854408
09AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine significantly attenuated cadmium-induced increases in hepatic myeloperoxidase activity.
In plain wordsIn mice, carnosine reduced liver myeloperoxidase activity compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
DecreaseMyeloperoxidase activity
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Inflammation markers · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Also, the reductions in hepatic nitric oxide and zinc ion levels, and the increases in hepatic cadmium ion concentration, and myeloperoxidase and caspase-3 activities following cadmium exposure were significantly attenuated by carnosine treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854409
10AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine significantly attenuated cadmium-induced increases in hepatic caspase-3 activity.
In plain wordsIn mice, carnosine reduced liver caspase-3 activity compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
DecreaseCaspase-3 activity
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Liver fat and liver function · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
Also, the reductions in hepatic nitric oxide and zinc ion levels, and the increases in hepatic cadmium ion concentration, and myeloperoxidase and caspase-3 activities following cadmium exposure were significantly attenuated by carnosine treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854410
11AnimalAnimal study (in vivo)Efficacy outcome
In mice, carnosine markedly ameliorated cadmium-induced liver tissue damage on light and electron microscopy.
In plain wordsIn mice, carnosine reduced liver tissue damage compared with cadmium exposure without carnosine.
Peptide
L-carnosine
Outcome
DecreaseLiver tissue damage
Study
mousen: not reported in source
cadmium-induced acute liver injury
Comparator
cadmium exposure without carnosine
Outcome group
Liver fat and liver function · Liver
Studied dose
10mg/kg/day · intraperitoneal · three consecutive daysAs given in this study (mouse).
Source sentences
Summary
In addition, carnosine markedly ameliorated cadmium-induced liver tissue damage as evidenced by light and electron microscopic examinations.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p.) was applied for three consecutive days, starting one day before…
Report a problemFND-1974854411

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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