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Study · Not a test of the peptide alone · 2009

4 results

Testosterone partially ameliorates metabolic profile and erectile responsiveness to PDE5 inhibitors in an animal model of male metabolic syndrome.

Filippi S, Vignozzi L, Morelli A, Chavalmane AK, Sarchielli E, Fibbi B, Saad F, Sandner P, Ruggiano P, Vannelli GB, Mannucci E, Maggi M

The journal of sexual medicine1 Sept 2009Cited by 128 (Europe PMC)

PMID19732305 (opens in a new tab)DOI10.1111/j.1743-6109.2009.01467.x (opens in a new tab)PepBankPUB-19732305
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 01AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism

    In rabbits, triptorelin induced a hypogonadal phenotype similar to that associated with a high-fat diet.

    In plain wordsIn rabbits, triptorelin induced a hypogonadal phenotype similar to that associated with a high-fat diet.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableHypogonadal phenotype
    Study

    Rabbitn: not reported in source

    Triptorelin-induced hypogonadism
    Comparator
    Control rabbits
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Such a phenotype is similar to that induced by triptorelin administration.
    2 context sentences
    Summary · context
    HFD induced hypogonadotropic hypogonadism is characterized by a reduction of plasma T, FSH, LH levels, testis and seminal vesicles weight, and testicular steroidogenic enzymes.
    Summary · context
    Male rabbits fed a high-fat diet (HFD), with or without testosterone (T) supplementation, were compared with control rabbits (fed a standard chow) and with rabbits made hypogonadal by a single injection of a long-acting GnRH-analog, triptorelin.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 02AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism

    In rabbits, triptorelin induced penile functional alterations similar to those associated with a high-fat diet.

    In plain wordsIn rabbits, triptorelin induced penile functional alterations similar to those associated with a high-fat diet.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedPenile functional alterations
    Study

    Rabbitn: not reported in source

    Triptorelin-induced hypogonadism
    Comparator
    Control rabbits
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Similar penile alterations were observed in triptorelin treated rabbit.
    2 context sentences
    Summary · context
    HFD also induced penile alterations, as demonstrated by a reduction of acetylcholine-and electrical field stimulation-induced CC relaxation, hyper-responsiveness to the NO donor, SNP, and unresponsiveness to PDE5 inhibitors.
    Summary · context
    Male rabbits fed a high-fat diet (HFD), with or without testosterone (T) supplementation, were compared with control rabbits (fed a standard chow) and with rabbits made hypogonadal by a single injection of a long-acting GnRH-analog, triptorelin.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 03AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism

    In rabbits treated with triptorelin, penile PDE5 mRNA expression decreased significantly versus controls.

    In plain wordsIn rabbits treated with triptorelin, penile PDE5 mRNA expression decreased significantly versus controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePDE5 mRNA expression
    Study

    Rabbitn: not reported in source

    Triptorelin-induced hypogonadism
    Comparator
    Control rabbits
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In HFD, as well as in triptorelin treated rabbits, PDE5 and eNOS mRNA expression quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) were significantly decreased.
    1 context sentence
    Summary · context
    Male rabbits fed a high-fat diet (HFD), with or without testosterone (T) supplementation, were compared with control rabbits (fed a standard chow) and with rabbits made hypogonadal by a single injection of a long-acting GnRH-analog, triptorelin.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  4. 04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism

    In rabbits treated with triptorelin, penile eNOS mRNA expression decreased significantly versus controls.

    In plain wordsIn rabbits treated with triptorelin, penile eNOS mRNA expression decreased significantly versus controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseeNOS mRNA expression
    Study

    Rabbitn: not reported in source

    Triptorelin-induced hypogonadism
    Comparator
    Control rabbits
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In HFD, as well as in triptorelin treated rabbits, PDE5 and eNOS mRNA expression quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) were significantly decreased.
    1 context sentence
    Summary · context
    Male rabbits fed a high-fat diet (HFD), with or without testosterone (T) supplementation, were compared with control rabbits (fed a standard chow) and with rabbits made hypogonadal by a single injection of a long-acting GnRH-analog, triptorelin.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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