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Study · In vitro (cells) · 2009

2 results

Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.

Hashimoto Y, Kurita M, Matsuoka M

Biochemical and biophysical research communications22 Aug 2009Cited by 23 (Europe PMC)

PMID19703422 (opens in a new tab)DOI10.1016/j.bbrc.2009.08.095 (opens in a new tab)PepBankPUB-19703422
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In neuronal cells lacking full-length WSX-1, soluble WSX-1 enabled Humanin to rescue Alzheimer's disease-relevant neuronal death.

    In plain wordsIn cells, a short form of the WSX-1 receptor let Humanin protect nerve cells from death linked to Alzheimer's disease.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin rescue of Alzheimer's disease-relevant neuronal death with soluble WSX-1
    Study

    n: not reported in source

    Neuronal cells lacking full-length WSX-1
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We here report that an alternatively spliced WSX-1 isoform, encoding an extracellular 270-amino-acid region of WSX-1 with cytokine-binding regions (named soluble WSX-1; sWSX-1), is expressed in neuronal cells lacking function of full-length WSX-1 and enables HN to rescue AD-relevant death.

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 02LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    An alternatively spliced soluble WSX-1 isoform was expressed in neuronal cells that lack full-length WSX-1 function.

    In plain wordsIn cells, nerve cells without working full-length WSX-1 still made a short form of this Humanin receptor part.

    Peptide
    Humanin
    Outcome
    Not applicableSoluble WSX-1 expression in neuronal cells
    Study

    n: not reported in source

    Neuronal cells lacking full-length WSX-1
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    an alternatively spliced WSX-1 isoform, encoding an extracellular 270-amino-acid region of WSX-1 with cytokine-binding regions (named soluble WSX-1; sWSX-1), is expressed in neuronal cells lacking function of full-length WSX-1

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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