Thymosin-beta4 attenuates ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes by inhibiting apoptosis.

Yang H, Cui GB, Jiao XY, Wang J, Ju G, You SW

Cellular and molecular neurobiology18 Aug 2009Cited by 13 (Europe PMC)

PMID19688260PMCIDPMC11498471DOI10.1007/s10571-009-9439-6PepBankPUB-19688260

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In cultured cortical astrocytes exposed to ethanol, Tβ4 markedly promoted cell viability.
In plain wordsIn cells, Tβ4 helped astrocytes stay alive when they were exposed to ethanol.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAstrocyte cell viability after ethanol
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
Tbeta4 markedly promoted cell viability
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826001
02LabIn vitro (cells)Efficacy outcome
In ethanol-treated cultured astrocytes, Tβ4 ameliorated the injury of GFAP-immunopositive cytoskeletal structures.
In plain wordsIn cells, Tβ4 reduced ethanol damage to the cell skeleton of astrocytes.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseGFAP-positive cytoskeletal injury
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
ameliorated the injury of intracellular glial fibrillary acidic protein-immunopositive cytoskeletal structures
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826002
03LabIn vitro (cells)Efficacy outcome
In ethanol-treated cultured astrocytes, Tβ4 reduced the percentage of apoptotic cells.
In plain wordsIn cells, Tβ4 lowered the share of astrocytes that died by programmed cell death after ethanol.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePercentage of apoptotic astrocytes
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
reduced the percentage of apoptotic astrocyte and cellular DNA fragmentation
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826003
04LabIn vitro (cells)Efficacy outcome
In ethanol-treated cultured astrocytes, Tβ4 reduced cellular DNA fragmentation.
In plain wordsIn cells, Tβ4 reduced DNA breakdown in astrocytes exposed to ethanol.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCellular DNA fragmentation
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
reduced the percentage of apoptotic astrocyte and cellular DNA fragmentation
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826004
05LabIn vitro (cells)Efficacy outcome
In ethanol-treated cultured astrocytes, Tβ4 suppressed caspase-3 activity.
In plain wordsIn cells, Tβ4 lowered the activity of caspase-3, an enzyme of cell death, after ethanol.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCaspase-3 activity
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
suppressed caspase-3 activity and upregulated Bcl-2 expression, inhibited the accumulation of reactive oxygen species and production of malondialdehyde in ethanol-treated astrocytes in a time-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826005
06LabIn vitro (cells)Efficacy outcome
In ethanol-treated cultured astrocytes, Tβ4 upregulated Bcl-2 expression.
In plain wordsIn cells, Tβ4 raised the level of Bcl-2, a protein that protects cells from death, after ethanol.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseBcl-2 expression
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
upregulated Bcl-2 expression, inhibited the accumulation of reactive oxygen species and production of malondialdehyde in ethanol-treated astrocytes in a time-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826006
07LabIn vitro (cells)Efficacy outcome
In ethanol-treated cultured astrocytes, Tβ4 inhibited the accumulation of reactive oxygen species.
In plain wordsIn cells, Tβ4 reduced the build-up of reactive oxygen molecules in astrocytes exposed to ethanol.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseReactive oxygen species accumulation
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
inhibited the accumulation of reactive oxygen species
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826007
08LabIn vitro (cells)Efficacy outcome
In ethanol-treated cultured astrocytes, Tβ4 inhibited the production of malondialdehyde.
In plain wordsIn cells, Tβ4 reduced malondialdehyde, a marker of oxidative damage, in astrocytes exposed to ethanol.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseMalondialdehyde production
Study
n: not reported in source
Cultured cerebral cortical astrocytes
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 microg/mlAs given in this study.
Source sentences
Summary
production of malondialdehyde in ethanol-treated astrocytes in a time-dependent manner
1 context sentence(design, population, supporting numbers)
Summary · context
Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively.
Report a problemFND-1968826008

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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