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Study · Animal study (in vivo) · rhesus monkey · 2009

10 results

Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones.

Ramaswamy S, Gibbs RB, Plant TM

Journal of neuroendocrinology21 Jul 2009Cited by 38 (Europe PMC)

PMID19686451 (opens in a new tab)PMCIDPMC2760459 (opens in a new tab)DOI10.1111/j.1365-2826.2009.01905.x (opens in a new tab)PepBankPUB-19686451
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, intravenous kisspeptin‑10 did not change circulating growth hormone.

    In plain wordsIn male rhesus monkeys, kisspeptin‑10 did not change growth hormone levels in blood.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma GH after kisspeptin-10
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    kisspeptin administration failed to influence circulating concentrations of GH, prolactin, TSH and cortisol
    1 context sentence
    Summary · context
    Second, the secretion of non-gonadotrophin adenohypophysial hormones [growth hormone (GH), prolactin and thyroid-stimulating hormone (TSH)] and cortisol in response to i.v. kisspeptin administration was examined.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, intravenous kisspeptin‑10 did not change circulating prolactin.

    In plain wordsIn male rhesus monkeys, kisspeptin‑10 did not change prolactin levels in blood.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma prolactin after kisspeptin-10
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    kisspeptin administration failed to influence circulating concentrations of GH, prolactin, TSH and cortisol
    1 context sentence
    Summary · context
    Second, the secretion of non-gonadotrophin adenohypophysial hormones [growth hormone (GH), prolactin and thyroid-stimulating hormone (TSH)] and cortisol in response to i.v. kisspeptin administration was examined.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, intravenous kisspeptin‑10 did not change circulating thyroid-stimulating hormone.

    In plain wordsIn male rhesus monkeys, kisspeptin‑10 did not change thyroid-stimulating hormone levels in blood.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma TSH after kisspeptin-10
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    kisspeptin administration failed to influence circulating concentrations of GH, prolactin, TSH and cortisol
    1 context sentence
    Summary · context
    Second, the secretion of non-gonadotrophin adenohypophysial hormones [growth hormone (GH), prolactin and thyroid-stimulating hormone (TSH)] and cortisol in response to i.v. kisspeptin administration was examined.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, intravenous kisspeptin‑10 did not change circulating cortisol.

    In plain wordsIn male rhesus monkeys, kisspeptin‑10 did not change cortisol levels in blood.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma cortisol after kisspeptin-10
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    kisspeptin administration failed to influence circulating concentrations of GH, prolactin, TSH and cortisol
    1 context sentence
    Summary · context
    Second, the secretion of non-gonadotrophin adenohypophysial hormones [growth hormone (GH), prolactin and thyroid-stimulating hormone (TSH)] and cortisol in response to i.v. kisspeptin administration was examined.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In adult male rhesus monkeys, the body's own kisspeptin-containing cells were found in the intermediate lobe of the pituitary in all animals.

    In plain wordsIn rhesus monkeys, the body's own kisspeptin was found in cells of the pituitary intermediate lobe.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin cells in intermediate lobe
    Study

    rhesus monkeyn = 8

    adult male rhesus monkeys
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Kisspeptin cells were found in the intermediate lobe of all animals
    1 context sentence
    Summary · context
    Eight animals were deeply anaesthetised and transcardially perfused with 4% paraformaldehyde.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 06AnimalEndogenous levelAnimal study (in vivo)Other

    In four of the adult male rhesus monkeys, the body's own kisspeptin was also seen in cells scattered in the periphery of the anterior pituitary lobe.

    In plain wordsIn four rhesus monkeys, the body's own kisspeptin was also seen in cells at the edge of the front pituitary lobe.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin cells in anterior lobe periphery
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Kisspeptin cells were found in the intermediate lobe of all animals and, in four monkeys, this neuropeptide was also observed in cells scattered in the periphery of the anterior lobe.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 07AnimalEndogenous levelAnimal study (in vivo)Other

    In rhesus monkey pituitary, kisspeptin colocalised with alpha-MSH-immunopositive cells in the intermediate lobe.

    In plain wordsIn rhesus monkeys, the body's own kisspeptin was found in the same pituitary cells as alpha-MSH.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin colocalisation with alpha-MSH cells
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Kisspeptin colocalised with alpha-MSH-immunopositive cells in the intermediate lobe and, in 50% of the monkeys, with ACTH-immuunopositive cells in the periphery of the adenohypophysis.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  4. 08AnimalEndogenous levelAnimal study (in vivo)Other

    In 50% of the rhesus monkeys, kisspeptin colocalised with ACTH-immunopositive cells in the periphery of the adenohypophysis.

    In plain wordsIn half of the rhesus monkeys, the body's own kisspeptin was found in the same pituitary cells as ACTH.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin colocalisation with ACTH cells
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Kisspeptin colocalised with alpha-MSH-immunopositive cells in the intermediate lobe and, in 50% of the monkeys, with ACTH-immuunopositive cells in the periphery of the adenohypophysis.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  5. 09AnimalEndogenous levelAnimal study (in vivo)Other

    In rhesus monkey pituitary, there was no evidence for colocalisation of kisspeptin with gonadotrophs, somatotrophs or lactotrophs.

    In plain wordsIn rhesus monkeys, the body's own kisspeptin was not found in the pituitary cells that make gonadotropins, growth hormone or prolactin.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin colocalisation with gonadotrophs, somatotrophs and lactotrophs
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    There was no evidence for colocalisation of kisspeptin with gonadotrophs, somatotrophs or lactotrophs.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  6. 10AnimalEndogenous levelAnimal study (in vivo)Other

    In rhesus monkey pituitary, beaded kisspeptin axons were observed in the neural lobe.

    In plain wordsIn rhesus monkeys, nerve fibres containing the body's own kisspeptin were seen in the back pituitary lobe.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin axons in neural lobe
    Study

    rhesus monkeyn: not reported in source

    adult male rhesus monkeys
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Beaded kisspeptin axons were observed in the neural lobe.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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