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Study · Non-randomized trial · n = 68 · 2009

7 results

[Use of cortexin in the early rehabilitation period of ischemic stroke of moderate severity].

Nurguzhaev ES, Mitrokhin DA, Izbasarova ASh, Nurguzhaev AE, Raimkulov BN, Abdil'manova BR

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2009

PMID19672239 (opens in a new tab)PepBankPUB-19672239
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients after ischemic stroke, global state improved in 77.1% with cortexin versus 54.5% with basic therapy alone.

    In plain wordsAfter ischemic stroke, global state improved in 77.1% with cortexin versus 54.5% with basic therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseGlobal state improvement
    Study

    n = 68

    Comparator
    basic therapy alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 mg daily · intramuscular · 10 daysAs given in this study (human).

    Measurements

    Patients with global improvement
    27 patients
    cortexin
    Global improvement proportion
    77.1%
    cortexin
    Patients with global improvement
    18 patients
    basic therapy alone
    Global improvement proportion
    54.5%
    basic therapy alone

    Source sentences

    Summary
    To the end of treatment, the improvement in global state was seen in 27 (77,1%) of patients of the main group and 18 (54,5%) patients of the control group.
    3 context sentences
    Summary · context
    Sixty-eight patients (mean age 60,5+/-2,8 years) in the early rehabilitation period of ischemic stroke were included in the study.
    Summary · context
    Thirty-five patients of the main group received peptide cortexin in dose of 10 mg daily intramuscular in the complex therapy, 33 patients of the control group received only the basic therapy.
    Summary · context
    Treatment duration was 10 days.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients after ischemic stroke, cortexin improved motor rehabilitation more than basic therapy alone.

    In plain wordsAfter ischemic stroke, cortexin improved motor rehabilitation more than basic therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseMotor function rehabilitation
    Study

    n = 68

    Comparator
    basic therapy alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 mg daily · intramuscular · 10 daysAs given in this study (human).

    Source sentences

    Summary
    The significantly better rehabilitation (p<0,05) of motor and cognitive functions after stroke damage, improvement in the brain bioelectric activity (the increase of alpha-activity and the decrease of slow-wave activity and sharp waves in the projection of ischemic zone) were found in patients treated with cortexin.
    3 context sentences
    Summary · context
    Sixty-eight patients (mean age 60,5+/-2,8 years) in the early rehabilitation period of ischemic stroke were included in the study.
    Summary · context
    Thirty-five patients of the main group received peptide cortexin in dose of 10 mg daily intramuscular in the complex therapy, 33 patients of the control group received only the basic therapy.
    Summary · context
    Treatment duration was 10 days.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients after ischemic stroke, cortexin improved cognitive rehabilitation more than basic therapy alone.

    In plain wordsAfter ischemic stroke, cortexin improved cognitive rehabilitation more than basic therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseCognitive function rehabilitation
    Study

    n = 68

    Comparator
    basic therapy alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    10 mg daily · intramuscular · 10 daysAs given in this study (human).

    Source sentences

    Summary
    The significantly better rehabilitation (p<0,05) of motor and cognitive functions after stroke damage, improvement in the brain bioelectric activity (the increase of alpha-activity and the decrease of slow-wave activity and sharp waves in the projection of ischemic zone) were found in patients treated with cortexin.
    3 context sentences
    Summary · context
    Sixty-eight patients (mean age 60,5+/-2,8 years) in the early rehabilitation period of ischemic stroke were included in the study.
    Summary · context
    Thirty-five patients of the main group received peptide cortexin in dose of 10 mg daily intramuscular in the complex therapy, 33 patients of the control group received only the basic therapy.
    Summary · context
    Treatment duration was 10 days.
  4. 04HumanNon-randomized trialEfficacy outcome

    In patients after ischemic stroke, cortexin increased EEG alpha activity compared with basic therapy alone.

    In plain wordsAfter ischemic stroke, cortexin increased EEG alpha activity compared with basic therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseEEG alpha activity
    Study

    n = 68

    Comparator
    basic therapy alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 mg daily · intramuscular · 10 daysAs given in this study (human).

    Source sentences

    Summary
    The significantly better rehabilitation (p<0,05) of motor and cognitive functions after stroke damage, improvement in the brain bioelectric activity (the increase of alpha-activity and the decrease of slow-wave activity and sharp waves in the projection of ischemic zone) were found in patients treated with cortexin.
    3 context sentences
    Summary · context
    Sixty-eight patients (mean age 60,5+/-2,8 years) in the early rehabilitation period of ischemic stroke were included in the study.
    Summary · context
    Thirty-five patients of the main group received peptide cortexin in dose of 10 mg daily intramuscular in the complex therapy, 33 patients of the control group received only the basic therapy.
    Summary · context
    Treatment duration was 10 days.
  5. 05HumanNon-randomized trialEfficacy outcome

    In patients after ischemic stroke, cortexin reduced EEG slow-wave activity compared with basic therapy alone.

    In plain wordsAfter ischemic stroke, cortexin reduced EEG slow-wave activity compared with basic therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseEEG slow-wave activity
    Study

    n = 68

    Comparator
    basic therapy alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 mg daily · intramuscular · 10 daysAs given in this study (human).

    Source sentences

    Summary
    The significantly better rehabilitation (p<0,05) of motor and cognitive functions after stroke damage, improvement in the brain bioelectric activity (the increase of alpha-activity and the decrease of slow-wave activity and sharp waves in the projection of ischemic zone) were found in patients treated with cortexin.
    3 context sentences
    Summary · context
    Sixty-eight patients (mean age 60,5+/-2,8 years) in the early rehabilitation period of ischemic stroke were included in the study.
    Summary · context
    Thirty-five patients of the main group received peptide cortexin in dose of 10 mg daily intramuscular in the complex therapy, 33 patients of the control group received only the basic therapy.
    Summary · context
    Treatment duration was 10 days.
  6. 06HumanNon-randomized trialEfficacy outcome

    In patients after ischemic stroke, cortexin reduced EEG sharp waves in the ischemic zone compared with basic therapy alone.

    In plain wordsAfter ischemic stroke, cortexin reduced EEG sharp waves in the ischemic zone compared with basic therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseEEG sharp waves in ischemic zone
    Study

    n = 68

    Comparator
    basic therapy alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 mg daily · intramuscular · 10 daysAs given in this study (human).

    Source sentences

    Summary
    The significantly better rehabilitation (p<0,05) of motor and cognitive functions after stroke damage, improvement in the brain bioelectric activity (the increase of alpha-activity and the decrease of slow-wave activity and sharp waves in the projection of ischemic zone) were found in patients treated with cortexin.
    3 context sentences
    Summary · context
    Sixty-eight patients (mean age 60,5+/-2,8 years) in the early rehabilitation period of ischemic stroke were included in the study.
    Summary · context
    Thirty-five patients of the main group received peptide cortexin in dose of 10 mg daily intramuscular in the complex therapy, 33 patients of the control group received only the basic therapy.
    Summary · context
    Treatment duration was 10 days.
  7. 07HumanNon-randomized trialSafety outcome

    In patients after ischemic stroke, no side effects of cortexin treatment were observed.

    In plain wordsAfter ischemic stroke, no side effects of cortexin treatment were observed.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Not applicableTreatment side effects
    Study

    n = 35

    Outcome group
    Adverse events · Whole body
    Studied dose
    10 mg daily · intramuscular · 10 daysAs given in this study (human).

    Source sentences

    Summary
    No side-effects of the treatment were observed.
    3 context sentences
    Summary · context
    Sixty-eight patients (mean age 60,5+/-2,8 years) in the early rehabilitation period of ischemic stroke were included in the study.
    Summary · context
    Thirty-five patients of the main group received peptide cortexin in dose of 10 mg daily intramuscular in the complex therapy, 33 patients of the control group received only the basic therapy.
    Summary · context
    Treatment duration was 10 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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