In binding studies with neuronal cell lines and rat and mouse brain and stomach membranes, radiolabelled Humanin derivatives showed no confirmed specific binding sites for Humanin on neuronal tissue.
In plain wordsIn lab tests, radiolabelled Humanin-like peptides did not confirm specific binding sites for Humanin on nerve tissue.
- Peptide
- Humanin
- Outcome
- No significant changeSpecific binding sites for humanin derivatives on neuronal tissue
- Study
n: not reported in source
Neuronal cell lines and rat and mouse brain and stomach membranes- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
Source sentences
Under the experimental conditions used, our data do not confirm the existence of specific binding sites for HN on the neuronal tissue.
1 context sentence(design, population, supporting numbers)
The pure monoradioiodinated peptides were used in: (i) in vitro binding studies with various neuronal cell lines and with brain and stomach membranes from rats and mice and (ii) in vivo biodistribution studies in rats and mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.