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Study · Observational study · n = 47 · 2009

7 results

Growth outcome during GnRH agonist treatments for slowly progressive central precocious puberty.

Massart F, Federico G, Harrell JC, Saggese G

Neuroendocrinology30 Jul 2009Cited by 22 (Europe PMC)

PMID19641297 (opens in a new tab)DOI10.1159/000231994 (opens in a new tab)PepBankPUB-19641297
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In girls with slowly progressive CPP, bone maturation did not differ significantly between triptorelin and leuprorelin treatment.

    In plain wordsIn girls with slowly progressive CPP, bone maturation did not differ significantly between triptorelin and leuprorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeBone maturation
    Study

    n = 47

    Comparator
    Leuprorelin acetate
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 36.5 +/- 0.7 monthsAs given in this study (human).

    Source sentences

    Summary
    No difference in bone maturation was detected (p > 0.05; TR vs. LA group), however compared to LA, TR treatment resulted in significantly higher Ht after 24 months (p < 0.05; LA vs. TR group).
    1 context sentence
    Summary · context
    We evaluated the growth outcome of 26 spCPP girls treated with triptorelin (TR) and 21 with leuprorelin acetate (LA) for 36.5 +/- 0.7 months.
  2. 02HumanObservational studyEfficacy outcome

    In girls with slowly progressive CPP, triptorelin was linked to greater height after 24 months than leuprorelin.

    In plain wordsIn girls with slowly progressive CPP, triptorelin was linked to greater height after 24 months than leuprorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseHeight after 24 months
    Study

    n = 47

    Comparator
    Leuprorelin acetate
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 36.5 +/- 0.7 monthsAs given in this study (human).

    Source sentences

    Summary
    No difference in bone maturation was detected (p > 0.05; TR vs. LA group), however compared to LA, TR treatment resulted in significantly higher Ht after 24 months (p < 0.05; LA vs. TR group).
    1 context sentence
    Summary · context
    We evaluated the growth outcome of 26 spCPP girls treated with triptorelin (TR) and 21 with leuprorelin acetate (LA) for 36.5 +/- 0.7 months.
  3. 03HumanObservational studyEfficacy outcome

    In girls with slowly progressive CPP, triptorelin was linked to higher final height SDS than leuprorelin.

    In plain wordsIn girls with slowly progressive CPP, triptorelin was linked to higher final height SDS than leuprorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseFinal height SDS
    Study

    n = 47

    Comparator
    Leuprorelin acetate
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 36.5 +/- 0.7 monthsAs given in this study (human).

    Source sentences

    Summary
    Although target height (TH) standard deviation score (SDS) and predicted adult height (PAH)-SDS at diagnosis were similar in both spCPP groups (p > 0.05; LA vs. TR group), final height (FH-SDS) was lower in LA-treated subjects (p < 0.05; LA vs. TR group).
    1 context sentence
    Summary · context
    We evaluated the growth outcome of 26 spCPP girls treated with triptorelin (TR) and 21 with leuprorelin acetate (LA) for 36.5 +/- 0.7 months.
  4. 04HumanObservational studyEfficacy outcome

    In girls with slowly progressive CPP, triptorelin was linked to higher estradiol levels than leuprorelin during the 12 months after GnRHa administration.

    In plain wordsIn girls with slowly progressive CPP, triptorelin was linked to higher estradiol than leuprorelin during the 12 months after treatment administration.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseEstradiol levels
    Study

    n = 47

    Comparator
    Leuprorelin acetate
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 36.5 +/- 0.7 monthsAs given in this study (human).

    Source sentences

    Summary
    Ht-SDS correlated with 17beta-estradiol (E(2)) blood levels in both spCPP groups (p < 0.0001) throughout GnRHa treatment, and E(2) values were higher in the TR- than in the LA-treated patients during the 12 months after GnRHa administration (p < 0.05; LA vs. TR group).
    1 context sentence
    Summary · context
    We evaluated the growth outcome of 26 spCPP girls treated with triptorelin (TR) and 21 with leuprorelin acetate (LA) for 36.5 +/- 0.7 months.

Studies that did not test the peptide alone3

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome

    In girls with slowly progressive CPP, growth progressively decelerated in both triptorelin and leuprorelin treatment groups.

    In plain wordsIn girls with slowly progressive CPP, growth progressively decelerated in both triptorelin and leuprorelin treatment groups.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseGrowth deceleration
    Study

    n = 47

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    GnRHa treatment induced a progressive growth deceleration in both spCPP groups.
    1 context sentence
    Summary · context
    We evaluated the growth outcome of 26 spCPP girls treated with triptorelin (TR) and 21 with leuprorelin acetate (LA) for 36.5 +/- 0.7 months.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome

    In both triptorelin and leuprorelin groups, final height SDS was significantly lower than target height SDS.

    In plain wordsIn both triptorelin and leuprorelin groups, final height scores were significantly below target height scores.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseFinal height versus target height
    Study

    n = 47

    Comparator
    Target height SDS
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    In both spCPP groups, FH-SDS was significantly lower than TH-SDS (p 0.05).
    1 context sentence
    Summary · context
    We evaluated the growth outcome of 26 spCPP girls treated with triptorelin (TR) and 21 with leuprorelin acetate (LA) for 36.5 +/- 0.7 months.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome

    In both triptorelin and leuprorelin groups, final height SDS was not significantly below predicted adult height SDS at diagnosis.

    In plain wordsIn both triptorelin and leuprorelin groups, final height scores were not significantly below the adult height scores predicted at diagnosis.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFinal height versus predicted adult height
    Study

    n = 47

    Comparator
    Predicted adult height SDS at diagnosis
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    In both spCPP groups, FH-SDS was significantly lower than TH-SDS (p 0.05).
    1 context sentence
    Summary · context
    We evaluated the growth outcome of 26 spCPP girls treated with triptorelin (TR) and 21 with leuprorelin acetate (LA) for 36.5 +/- 0.7 months.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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