Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.

Ho JH, Ma WH, Su Y, Tseng KC, Kuo TK, Lee OK

Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Jan 2010Cited by 21 (Europe PMC)

PMID19637215DOI10.1002/jor.20956PepBankPUB-19637215

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 decreased F-actin formation.
In plain wordsIn cells, Tβ4 reduced the formation of F-actin, a part of the cell skeleton.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseF-actin formation
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) decreased F-actin formation, reduced the F-actin/G-actin ratio, and inhibited osteogenic differentiation
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721501
02LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 reduced the F-actin/G-actin ratio.
In plain wordsIn cells, Tβ4 lowered the ratio of F-actin to G-actin in the cell skeleton.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseF-actin/G-actin ratio
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) decreased F-actin formation, reduced the F-actin/G-actin ratio, and inhibited osteogenic differentiation
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721502
03LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 inhibited osteogenic differentiation.
In plain wordsIn cells, Tβ4 reduced the change of stem cells into bone-forming cells.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseOsteogenic differentiation
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) decreased F-actin formation, reduced the F-actin/G-actin ratio, and inhibited osteogenic differentiation
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721503
04LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, the actin changes caused by Tβ4 were not associated with a change of Runx2 gene expression during early osteogenic induction.
In plain wordsIn cells, the Tβ4 effect on the cell skeleton was not linked to a change in Runx2 gene activity.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeRunx2 gene expression during early osteogenic induction
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
such actin reorganization was not associated with the change of Runt-related transcription factor 2 gene expression during early osteogenic induction.
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721504
05LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 facilitated adipogenic differentiation.
In plain wordsIn cells, Tβ4 helped stem cells change into fat cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAdipogenic differentiation
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Besides, Tbeta(4) reciprocally facilitated adipogenic differentiation.
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721505
06LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 up-regulated the gene of an adipocyte adhesion molecule during early adipogenic differentiation.
In plain wordsIn cells, Tβ4 raised the gene activity of a cell adhesion molecule early in fat cell formation.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAdipocyte adhesion molecule gene expression
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) treatment was found to up-regulate gene as well as promote surface expression of adipocyte adhesion molecule during early adipogenic differentiation
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721506
07LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 promoted surface expression of an adipocyte adhesion molecule during early adipogenic differentiation.
In plain wordsIn cells, Tβ4 increased the amount of a cell adhesion molecule on the cell surface early in fat cell formation.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAdipocyte adhesion molecule surface expression
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) treatment was found to up-regulate gene as well as promote surface expression of adipocyte adhesion molecule during early adipogenic differentiation
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721507
08LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 treatment accompanied acceleration of adipocyte phenotypic maturation.
In plain wordsIn cells, Tβ4 treatment came with faster maturation of fat cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAdipocyte phenotypic maturation
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
which accompanied acceleration of adipocyte phenotypic maturation
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721508
09LabIn vitro (cells)Mechanism
In human mesenchymal stem cells, Tβ4 effects were not associated with differential PPAR gamma expression during the first week of adipogenic induction.
In plain wordsIn cells, the Tβ4 effects on fat cell formation were not linked to a change in PPAR gamma activity in week one.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changePPAR gamma expression during first week of adipogenic induction
Study
humann: not reported in source
Human mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
but was not associated with differential expression of peroxisome proliferator-activated receptor gamma during the first week of adipogenic induction.
2 context sentences(design, population, supporting numbers)
Title · context
Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.
Summary · context
The study investigated the ways in which Tbeta(4) regulates cell fate determination in MSCs upon differentiation induction.
Report a problemFND-1963721509

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Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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