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Study · Animal study (in vivo) · sheep · 2009

6 results

Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe.

Smith JT, Saleh SN, Clarke IJ

Neuroendocrinology7 Jul 2009Cited by 35 (Europe PMC)

PMID19590160 (opens in a new tab)DOI10.1159/000227806 (opens in a new tab)PepBankPUB-19590160
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Corriedale ewes, intravenous kisspeptin‑10 increased the concentration of LH in all animals.

    In plain wordsIn ewes, kisspeptin‑10 raised LH in the blood in all animals.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH concentration after kisspeptin-10
    Study

    sheepn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    20 or 250 µg · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    Kisspeptin treatment increased the concentration of luteinizing hormone (LH) in all animals.
    1 context sentence
    Summary · context
    Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 microg or maximal dose: 250 microg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ewes, the LH response to kisspeptin‑10 at 20 µg was greater during the anestrous period, about 4-fold that in the luteal phase.

    In plain wordsIn ewes, kisspeptin‑10 raised LH about four times more in the non-breeding season than in the luteal phase.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableLH response in anestrous versus luteal phase
    Study

    sheepn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    20 µg · intravenousAs given in this study (sheep).

    Measurements

    LH response ratio, anestrous versus luteal
    4 fold
    kisspeptin 20 µg

    Source sentences

    Summary
    We found the LH response to kisspeptin (20 microg) was greater in ewes during the anestrous period, being 4-fold that seen during the luteal phase of the estrous cycle.
    1 context sentence
    Summary · context
    Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 microg or maximal dose: 250 microg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ewes within the breeding season, kisspeptin‑10 at 20 µg was most effective on LH during the late-follicular phase.

    In plain wordsIn ewes, kisspeptin‑10 raised LH most during the late-follicular phase of the breeding season.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableLH response across breeding-season phases
    Study

    sheepn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    20 µg · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    Within the breeding season, kisspeptin (20 microg) was most effective during the late-follicular phase of the estrous cycle.
    1 context sentence
    Summary · context
    Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 microg or maximal dose: 250 microg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ewes, kisspeptin‑10 at 20 and 250 µg had no effect on plasma growth hormone.

    In plain wordsIn ewes, kisspeptin‑10 did not change blood growth hormone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma growth hormone
    Study

    sheepn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    20 and 250 µg · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    Kisspeptin treatment (both 20 and 250 microg) had no effect on plasma levels of growth hormone, prolactin or cortisol.
    1 context sentence
    Summary · context
    Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 microg or maximal dose: 250 microg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ewes, kisspeptin‑10 at 20 and 250 µg had no effect on plasma prolactin.

    In plain wordsIn ewes, kisspeptin‑10 did not change blood prolactin.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma prolactin
    Study

    sheepn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    20 and 250 µg · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    Kisspeptin treatment (both 20 and 250 microg) had no effect on plasma levels of growth hormone, prolactin or cortisol.
    1 context sentence
    Summary · context
    Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 microg or maximal dose: 250 microg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ewes, kisspeptin‑10 at 20 and 250 µg had no effect on plasma cortisol.

    In plain wordsIn ewes, kisspeptin‑10 did not change blood cortisol.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma cortisol
    Study

    sheepn: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    20 and 250 µg · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    Kisspeptin treatment (both 20 and 250 microg) had no effect on plasma levels of growth hormone, prolactin or cortisol.
    1 context sentence
    Summary · context
    Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 microg or maximal dose: 250 microg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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