Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats.

Hashizume T, Saito H, Sawada T, Yaegashi T, Ezzat AA, Sawai K, Yamashita T

Animal reproduction science1 Mar 2010Cited by 58 (Europe PMC)

PMID19574004DOI10.1016/j.anireprosci.2009.05.017PepBankPUB-19574004

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female goats, a single intravenous injection of kisspeptin‑10 at 1, 5 and 10 μg/kg stimulated the release of LH.
In plain wordsIn female goats, a single injection of kisspeptin‑10 raised LH release.
Peptide
Kisspeptin-10
Outcome
IncreaseLH release
Study
goatn = 4
Adult female goats in the luteal phase
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1, 5 and 10 μg/kg · intravenous · single injectionAs given in this study (goat).
Source sentences
Summary
A single intravenous (i.v.) injection of 1, 5 and 10 microg/kg b.w. (0.77, 3.85 and 7.69 nmol/kg b.w.) of Kp10 stimulated the release of LH.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were performed using four female goats (4-5 years old) in the luteal phase of estrous cycle.
Report a problemFND-1957400401
02AnimalAnimal study (in vivo)Efficacy outcome
In female goats, maximum LH values after kisspeptin‑10 injection came 20-30 min after the injection.
In plain wordsIn female goats, blood LH peaked 20 to 30 minutes after a kisspeptin‑10 injection.
Peptide
Kisspeptin-10
Outcome
Not applicableTime to maximum LH after injection
Study
goatn = 4
Adult female goats in the luteal phase
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1, 5 and 10 μg/kg · intravenous · single injectionAs given in this study (goat).
Measurements
Time to maximum LH
20 to 30 min
after injection
Source sentences
Summary
Maximum values were observed 20-30 min after the injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were performed using four female goats (4-5 years old) in the luteal phase of estrous cycle.
Report a problemFND-1957400402
03AnimalAnimal study (in vivo)Efficacy outcome
In female goats, kisspeptin‑10 did not significantly alter plasma growth hormone.
In plain wordsIn female goats, kisspeptin‑10 did not change blood growth hormone.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma GH concentration
Study
goatn = 4
Adult female goats in the luteal phase
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1, 5 and 10 μg/kg · intravenous · single injectionAs given in this study (goat).
Source sentences
Summary
Kp10 did not alter plasma GH and PRL concentrations significantly.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were performed using four female goats (4-5 years old) in the luteal phase of estrous cycle.
Report a problemFND-1957400403
04AnimalAnimal study (in vivo)Efficacy outcome
In female goats, kisspeptin‑10 did not significantly alter plasma prolactin.
In plain wordsIn female goats, kisspeptin‑10 did not change blood prolactin.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma PRL concentration
Study
goatn = 4
Adult female goats in the luteal phase
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1, 5 and 10 μg/kg · intravenous · single injectionAs given in this study (goat).
Source sentences
Summary
Kp10 did not alter plasma GH and PRL concentrations significantly.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were performed using four female goats (4-5 years old) in the luteal phase of estrous cycle.
Report a problemFND-1957400404
05AnimalAnimal study (in vivo)Efficacy outcome
In female goats, three consecutive injections of kisspeptin‑10 increased plasma LH after each injection.
In plain wordsIn female goats, three kisspeptin‑10 injections each raised blood LH.
Peptide
Kisspeptin-10
Outcome
IncreasePlasma LH after three injections
Study
goatn = 4
Adult female goats in the luteal phase
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 μg/kg, three injections 2 h apart · intravenous · three injections at 2-h intervalsAs given in this study (goat).
Source sentences
Summary
Three consecutive i.v. injections of Kp10 (5 microg/kg b.w.) or GnRH (5 microg/kg b.w.: 4.23 nmol/kg b.w.) at 2-h intervals increased both plasma LH and FSH levels after each injection (P<0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were performed using four female goats (4-5 years old) in the luteal phase of estrous cycle.
Report a problemFND-1957400405
06AnimalAnimal study (in vivo)Efficacy outcome
In female goats, three consecutive injections of kisspeptin‑10 increased plasma FSH after each injection.
In plain wordsIn female goats, three kisspeptin‑10 injections each raised blood FSH.
Peptide
Kisspeptin-10
Outcome
IncreasePlasma FSH after three injections
Study
goatn = 4
Adult female goats in the luteal phase
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 μg/kg, three injections 2 h apart · intravenous · three injections at 2-h intervalsAs given in this study (goat).
Source sentences
Summary
Three consecutive i.v. injections of Kp10 (5 microg/kg b.w.) or GnRH (5 microg/kg b.w.: 4.23 nmol/kg b.w.) at 2-h intervals increased both plasma LH and FSH levels after each injection (P<0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were performed using four female goats (4-5 years old) in the luteal phase of estrous cycle.
Report a problemFND-1957400406
07AnimalAnimal study (in vivo)Efficacy outcome
In female goats, the rate of decrease in LH and FSH after the peak was attenuated with kisspeptin‑10 compared with GnRH.
In plain wordsIn female goats, LH and FSH fell more slowly after the peak with kisspeptin‑10 than with GnRH.
Peptide
Kisspeptin-10
Outcome
DecreaseRate of decrease in LH and FSH after the peak
Study
goatn = 4
Adult female goats in the luteal phase
Comparator
GnRH 5 μg/kg
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 μg/kg · intravenous · single injectionAs given in this study (goat).
Source sentences
Summary
The rate of decrease in LH and FSH levels following the peak was attenuated in Kp10-treated compared to GnRH-treated animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were performed using four female goats (4-5 years old) in the luteal phase of estrous cycle.
Report a problemFND-1957400407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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