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Study · In vitro (cells) · 2009

7 results

KiSS1 suppresses TNFalpha-induced breast cancer cell invasion via an inhibition of RhoA-mediated NF-kappaB activation.

Cho SG, Li D, Stafford LJ, Luo J, Rodriguez-Villanueva M, Wang Y, Liu M

Journal of cellular biochemistry1 Aug 2009Cited by 58 (Europe PMC)

PMID19533666 (opens in a new tab)PMCIDPMC2745330 (opens in a new tab)DOI10.1002/jcb.22216 (opens in a new tab)PepBankPUB-19533666
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In breast cancer cells, kisspeptin‑10 inhibited TNFalpha-induced NF-kappaB activity.

    In plain wordsIn cells, kisspeptin‑10 reduced NF-kappaB activity caused by TNFalpha in breast cancer cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTNFalpha-induced NF-kappaB activity
    Study

    n: not reported in source

    breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both KiSS1 overexpression and KP10 (kisspeptin-10) stimulation inhibited TNFalpha-induced NF-kappaB activity, suppressed TNFalpha-induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation.
  2. 02LabIn vitro (cells)Efficacy outcome

    In breast cancer cells, kisspeptin‑10 suppressed TNFalpha-induced cell migration.

    In plain wordsIn cells, kisspeptin‑10 reduced the movement of breast cancer cells caused by TNFalpha.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTNFalpha-induced cell migration
    Study

    n: not reported in source

    breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both KiSS1 overexpression and KP10 (kisspeptin-10) stimulation inhibited TNFalpha-induced NF-kappaB activity, suppressed TNFalpha-induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation.
    1 context sentence
    Summary · context
    Furthermore, KP10 inhibited TNFalpha-induced cell migration and RhoA GTPase activation.
  3. 03LabIn vitro (cells)Efficacy outcome

    In breast cancer cells, kisspeptin‑10 suppressed TNFalpha-induced cell attachment to fibronectin.

    In plain wordsIn cells, kisspeptin‑10 reduced the attachment of breast cancer cells to fibronectin caused by TNFalpha.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTNFalpha-induced cell attachment to fibronectin
    Study

    n: not reported in source

    breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both KiSS1 overexpression and KP10 (kisspeptin-10) stimulation inhibited TNFalpha-induced NF-kappaB activity, suppressed TNFalpha-induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation.
  4. 04LabIn vitro (cells)Efficacy outcome

    In breast cancer cells, kisspeptin‑10 had little effect on proliferation.

    In plain wordsIn cells, kisspeptin‑10 had little effect on the growth of breast cancer cells.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeCancer cell proliferation
    Study

    n: not reported in source

    breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while KP10 has little effect on cancer cell proliferation.
  5. 05LabIn vitro (cells)Mechanism

    In breast cancer cells, kisspeptin‑10 inhibited TNFalpha-induced RhoA GTPase activation.

    In plain wordsIn cells, kisspeptin‑10 reduced RhoA activation caused by TNFalpha in breast cancer cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTNFalpha-induced RhoA GTPase activation
    Study

    n: not reported in source

    breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, KP10 inhibited TNFalpha-induced cell migration and RhoA GTPase activation.

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 06LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In breast cancer cells, KiSS1 overexpression inhibited TNFalpha-induced NF-kappaB activity.

    In plain wordsIn cells, extra KiSS1 gene activity reduced NF-kappaB activity caused by TNFalpha in breast cancer cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTNFalpha-induced NF-kappaB activity with KiSS1 overexpression
    Study

    n: not reported in source

    breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    Both KiSS1 overexpression and KP10 (kisspeptin-10) stimulation inhibited TNFalpha-induced NF-kappaB activity, suppressed TNFalpha-induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 07LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Efficacy outcome

    In breast cancer cells, KiSS1 overexpression suppressed TNFalpha-induced cell migration.

    In plain wordsIn cells, extra KiSS1 gene activity reduced the movement of breast cancer cells caused by TNFalpha.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTNFalpha-induced cell migration with KiSS1 overexpression
    Study

    n: not reported in source

    breast cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Both KiSS1 overexpression and KP10 (kisspeptin-10) stimulation inhibited TNFalpha-induced NF-kappaB activity, suppressed TNFalpha-induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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