Evidence for potential functionality of nuclearly-encoded humanin isoforms.

Bodzioch M, Lapicka-Bodzioch K, Zapala B, Kamysz W, Kiec-Wilk B, Dembinska-Kiec A

Genomics27 May 2009Cited by 107 (Europe PMC)

PMID19477263DOI10.1016/j.ygeno.2009.05.006PepBankPUB-19477263

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelEx vivo tissueOther
At least ten of the nuclear HN-like genes were expressed in human tissues.
In plain wordsAt least ten of the body's own nuclear humanin-like genes were active in human tissues.
Peptide
Humanin
Outcome
Not applicableExpression of nuclear HN-like genes
Study
humann: not reported in source
Human tissues
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
At least ten of these nuclear genes are expressed in human tissues,
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1947726302
02LabEndogenous levelIn vitro (cells)Other
The nuclear HN-like genes responded to staurosporine and beta-carotene.
In plain wordsIn cells, the body's own nuclear humanin-like genes responded to staurosporine and beta-carotene.
Peptide
Humanin
Outcome
Direction not reportedResponse of nuclear HN-like genes to staurosporine and beta-carotene
Study
humann: not reported in source
Human cells treated with staurosporine and beta-carotene
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
and respond to staurosporine (STS) and beta-carotene.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1947726303

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

03LabNot a test of Humanin aloneIn vitro (cells)Activity measurement
Cytoprotection against staurosporine-induced apoptosis by the polymorphic HN5 variant (threonine 13 replaced with isoleucine) was reduced compared with wild type HN5.
In plain wordsIn cells, a natural variant of a humanin-like peptide protected less against induced cell death than the standard form.
Peptide
Humanin
Outcome
DecreaseCytoprotection by the polymorphic HN5 variant
Study
n: not reported in source
Cells with staurosporine-induced apoptosis
Comparator
Wild type HN5
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Cytoprotection against the STS-induced apoptosis conferred by the polymorphic HN5 variant, in which threonine in position 13 is replaced with isoleucine, is reduced compared to the wild type HN5 peptide.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-1947726305
04Computer modelNot a test of Humanin aloneIn silicoOther
Bioinformatic data suggested 13 MT-RNR2-like nuclear loci that are predicted to keep open reading frames for 15 distinct full-length HN-like peptides.
In plain wordsA computer analysis predicted 13 gene copies in the nucleus that could make 15 humanin-like peptides.
Peptide
Humanin
Outcome
Not applicablePredicted nuclear MT-RNR2-like loci encoding HN-like peptides
Study
humann: not reported in source
Bioinformatic analysis of the genome
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
We provide bioinformatic and expression data suggesting the existence of 13 MT-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct full-length HN-like peptides.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-1947726301
05Computer modelNot a test of Humanin aloneIn silicoOther
Sequence comparisons of the nuclear HN isoforms and homologues in other species revealed two consensus motifs, at residues 5-11 and 14-19.
In plain wordsA computer comparison found two shared sequence motifs in nuclear humanin-like peptides and their relatives in other species.
Peptide
Humanin
Outcome
Not applicableConsensus motifs of nuclear HN isoforms
Study
n: not reported in source
Sequence comparison of nuclear HN isoforms and homologues
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Sequence comparisons of the nuclear HN isoforms and their homologues in other species reveal two consensus motifs, encompassing residues 5-11 (GFS/NCLLL), and 14-19 (SEIDLP/S).
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-1947726304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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