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Study · Animal study (in vivo) · rat · 2009

12 results

Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system.

Balenovic D, Bencic ML, Udovicic M, Simonji K, Hanzevacki JS, Barisic I, Kranjcevic S, Prkacin I, Coric V, Brcic L, Coric M, Brcic I and 6 more

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Borovic S, Radic B, Drmic D, Vrcic H, Seiwerth S, Sikiric P

Regulatory peptides22 May 2009Cited by 51 (Europe PMC)

PMID19465062 (opens in a new tab)DOI10.1016/j.regpep.2009.05.008 (opens in a new tab)PepBankPUB-19465062
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given increasing doses of methyldigoxin, BPC‑157 given intravenously before methyldigoxin reduced the number of ventricular premature beats.

    In plain wordsIn rats given a heart drug to cause toxicity, BPC‑157 given beforehand reduced the number of irregular heartbeats.

    Peptide
    BPC-157
    Outcome
    DecreaseVentricular premature beats (prophylaxis)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 microg, 10 microg, 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    reduced the number of ventricular premature beats
    1 context sentence
    Summary · context
    In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and digitalis toxicity. (i).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given increasing doses of methyldigoxin, BPC‑157 given intravenously before methyldigoxin prolonged the time before onset of ventricular tachycardia.

    In plain wordsIn rats given a heart drug to cause toxicity, BPC‑157 given beforehand delayed the start of fast abnormal heart rhythm.

    Peptide
    BPC-157
    Outcome
    IncreaseTime to onset of ventricular tachycardia (prophylaxis)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 microg, 10 microg, 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    prolonged the time before onset of ventricular tachycardia
    1 context sentence
    Summary · context
    In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and digitalis toxicity. (i).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats given increasing doses of methyldigoxin, BPC‑157 at microgram doses given intravenously before methyldigoxin reduced ventricular tachycardia duration.

    In plain wordsIn rats given a heart drug to cause toxicity, BPC‑157 given beforehand shortened episodes of fast abnormal heart rhythm.

    Peptide
    BPC-157
    Outcome
    DecreaseVentricular tachycardia duration (prophylaxis)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 microg, 10 microg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    reduced ventricular tachycardia and AV-block duration (microg-regimes)
    1 context sentence
    Summary · context
    In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and digitalis toxicity. (i).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats given increasing doses of methyldigoxin, BPC‑157 given intravenously before methyldigoxin reduced AV-block duration at all doses.

    In plain wordsIn rats given a heart drug to cause toxicity, BPC‑157 given beforehand shortened the time of heart conduction block.

    Peptide
    BPC-157
    Outcome
    DecreaseAV-block duration (prophylaxis)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 microg, 10 microg, 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    reduced ventricular tachycardia and AV-block duration (microg-regimes) or reduced mainly the AV-block duration (ng-regimen)
    1 context sentence
    Summary · context
    In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and digitalis toxicity. (i).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with advanced methyldigoxin toxicity, BPC‑157 applied at the 20th second of grade 3 AV-block shortened AV-blocks.

    In plain wordsIn rats with severe heart drug toxicity, BPC‑157 given during heart block shortened the block.

    Peptide
    BPC-157
    Outcome
    DecreaseAV-block duration (therapy)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 applied at the 20th second of the grade 3 AV-block shortened AV-blocks, mitigated a further digitalis toxicity course.
    1 context sentence
    Summary · context
    Advanced methyldigoxin toxicity (6.0 mg/kg i.v. bolus).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with advanced methyldigoxin toxicity, BPC‑157 applied during grade 3 AV-block mitigated the further course of digitalis toxicity.

    In plain wordsIn rats with severe heart drug toxicity, BPC‑157 given during heart block eased the later course of the toxicity.

    Peptide
    BPC-157
    Outcome
    DecreaseFurther digitalis toxicity course (therapy)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    mitigated a further digitalis toxicity course.
    1 context sentence
    Summary · context
    Advanced methyldigoxin toxicity (6.0 mg/kg i.v. bolus).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with advanced methyldigoxin toxicity, ventricular tachycardias were avoided with BPC‑157 50 microg.

    In plain wordsIn rats with severe heart drug toxicity, the high dose of BPC‑157 avoided fast abnormal heart rhythm.

    Peptide
    BPC-157
    Outcome
    DecreaseVentricular tachycardia, 50 microg (therapy)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 microgAs given in this study (rat).

    Source sentences

    Summary
    Ventricular tachycardias were either avoided (50 microg)
    1 context sentence
    Summary · context
    Advanced methyldigoxin toxicity (6.0 mg/kg i.v. bolus).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with advanced methyldigoxin toxicity, ventricular tachycardias were markedly reduced with BPC‑157 10 microg and 10 ng.

    In plain wordsIn rats with severe heart drug toxicity, lower doses of BPC‑157 markedly reduced fast abnormal heart rhythm.

    Peptide
    BPC-157
    Outcome
    DecreaseVentricular tachycardia, 10 microg and 10 ng (therapy)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 microg, 10 ngAs given in this study (rat).

    Source sentences

    Summary
    markedly reduced (10 microg, 10 ng)
    1 context sentence
    Summary · context
    Advanced methyldigoxin toxicity (6.0 mg/kg i.v. bolus).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with advanced methyldigoxin toxicity, fatal outcome was avoided with BPC‑157 50 microg.

    In plain wordsIn rats with severe heart drug toxicity, the high dose of BPC‑157 avoided death.

    Peptide
    BPC-157
    Outcome
    DecreaseFatal outcome, 50 microg (therapy)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Mortality · Whole body
    Studied dose
    50 microgAs given in this study (rat).

    Source sentences

    Summary
    Fatal outcome was either avoided (50 microg)
    1 context sentence
    Summary · context
    Advanced methyldigoxin toxicity (6.0 mg/kg i.v. bolus).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with advanced methyldigoxin toxicity, fatal outcome was reduced with BPC‑157 10 microg.

    In plain wordsIn rats with severe heart drug toxicity, a medium dose of BPC‑157 reduced deaths.

    Peptide
    BPC-157
    Outcome
    DecreaseFatal outcome, 10 microg (therapy)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Mortality · Whole body
    Studied dose
    10 microgAs given in this study (rat).

    Source sentences

    Summary
    Fatal outcome was either avoided (50 microg), reduced (10 microg)
    1 context sentence
    Summary · context
    Advanced methyldigoxin toxicity (6.0 mg/kg i.v. bolus).
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats with advanced methyldigoxin toxicity, fatal outcome was only delayed with BPC‑157 10 ng.

    In plain wordsIn rats with severe heart drug toxicity, the lowest dose of BPC‑157 only delayed death.

    Peptide
    BPC-157
    Outcome
    IncreaseTime to fatal outcome, 10 ng (therapy)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Mortality · Whole body
    Studied dose
    10 ngAs given in this study (rat).

    Source sentences

    Summary
    or only delayed (10 ng)
    1 context sentence
    Summary · context
    Advanced methyldigoxin toxicity (6.0 mg/kg i.v. bolus).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In rats with methyldigoxin arrhythmias, the antagonism of L-NAME with BPC‑157 produced an effect similar to BPC‑157 alone.

    In plain wordsIn rats with heart drug toxicity, BPC‑157 with L-NAME worked like BPC‑157 alone.

    Peptide
    BPC-157
    Outcome
    No significant changeEffect with L-NAME (NO-system interaction)
    Study

    ratn: not reported in source

    Methyldigoxin-induced arrhythmia
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    50 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    the antagonism of L-NAME with BPC 157 produced an effect similar to BPC 157 alone
    1 context sentence
    Summary · context
    In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and digitalis toxicity. (i).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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