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Study · Ex vivo tissue · mouse · 2009

3 results

Protective effect of S14G-humanin against beta-amyloid induced LTP inhibition in mouse hippocampal slices.

Zhang W, Miao J, Hao J, Li Z, Xu J, Liu R, Cao F, Wang R, Chen J, Li Z

Peptides13 Mar 2009Cited by 20 (Europe PMC)

PMID19463756 (opens in a new tab)DOI10.1016/j.peptides.2009.02.017 (opens in a new tab)PepBankPUB-19463756
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In mouse hippocampal slices, HNG significantly ameliorated the Abeta(25-35)-induced inhibition of early-phase LTP in a dose-dependent manner.

    In plain wordsIn mouse brain slices, the humanin analog HNG reduced the amyloid-induced block of early memory-related signalling.

    Peptide
    Humanin
    Outcome
    IncreaseEarly-phase LTP inhibited by Abeta(25-35)
    Study

    mousen: not reported in source

    Hippocampal slices with Abeta(25-35)-inhibited LTP
    Comparator
    Abeta(25-35) alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while HNG significantly ameliorated such inhibition of E-LTP and L-LTP in a dose-dependent manner.
    1 context sentence
    Summary · context
    The present study examined the effects of HNG on Abeta-induced inhibition of hippocampal long-term potentiation (LTP) in mouse hippocampal slices.
  2. 02LabEx vivo tissueEfficacy outcome

    In mouse hippocampal slices, HNG significantly ameliorated the Abeta(25-35)-induced inhibition of late-phase LTP in a dose-dependent manner.

    In plain wordsIn mouse brain slices, the humanin analog HNG reduced the amyloid-induced block of late memory-related signalling.

    Peptide
    Humanin
    Outcome
    IncreaseLate-phase LTP inhibited by Abeta(25-35)
    Study

    mousen: not reported in source

    Hippocampal slices with Abeta(25-35)-inhibited LTP
    Comparator
    Abeta(25-35) alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while HNG significantly ameliorated such inhibition of E-LTP and L-LTP in a dose-dependent manner.
    1 context sentence
    Summary · context
    The present study examined the effects of HNG on Abeta-induced inhibition of hippocampal long-term potentiation (LTP) in mouse hippocampal slices.
  3. 03LabEx vivo tissueMechanism

    In mouse hippocampal slices, HNG restored the Abeta(25-35)-induced reduction of phosphorylated CREB during L-LTP induction.

    In plain wordsIn mouse brain slices, the humanin analog HNG restored a memory-related signal (phosphorylated CREB) that the amyloid fragment had lowered.

    Peptide
    Humanin
    Outcome
    IncreasePhosphorylated CREB during L-LTP induction
    Study

    mousen: not reported in source

    Hippocampal slices with Abeta(25-35)-inhibited LTP
    Comparator
    Abeta(25-35) alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, the reduction of phosphorylated CREB trigged by Abeta(25-35) was restored by HNG during L-LTP induction, possibly attributing to the improvement of the L-LTP inhibition.
    1 context sentence
    Summary · context
    The present study examined the effects of HNG on Abeta-induced inhibition of hippocampal long-term potentiation (LTP) in mouse hippocampal slices.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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