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Study · Not a test of the peptide alone · 2009

3 results

Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration.

Fan Y, Gong Y, Ghosh PK, Graham LM, Fox PL

Developmental cell1 May 2009Cited by 55 (Europe PMC)

PMID19460343 (opens in a new tab)PMCIDPMC2692108 (opens in a new tab)DOI10.1016/j.devcel.2009.03.009 (opens in a new tab)PepBankPUB-19460343
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In endothelial cells, FRET analysis showed diminished interaction between thymosin-beta4 and G-actin at the cell leading edge despite colocalization.

    In plain wordsIn cells, thymosin-beta4 interacted less with G-actin at the front edge of moving cells, even though both were present there.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTbeta4 and G-actin interaction at the cell leading edge
    Study

    n: not reported in source

    Endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    In particular and quite unexpectedly, FRET analysis reveals diminished interaction between Tbeta4 and G-actin at the cell leading edge despite their colocalization there.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In endothelial cells, profilin-dependent dissociation of G-actin-Tbeta4 complexes facilitated Tbeta4 binding to integrin-linked kinase in the lamellipodia.

    In plain wordsIn cells, profilin freed thymosin-beta4 from actin so that it could bind integrin-linked kinase at the cell front.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTbeta4 binding to ILK in lamellipodia
    Study

    n: not reported in source

    Endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    Profilin-dependent dissociation of G-actin-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In endothelial cells, Tbeta4-ILK complexes recruited and activated Akt2, resulting in matrix metalloproteinase-2 production.

    In plain wordsIn cells, thymosin-beta4 bound to ILK activated Akt2, which led to production of matrix metalloproteinase-2.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAkt2 activation and matrix metalloproteinase-2 production by Tbeta4-ILK complexes
    Study

    n: not reported in source

    Endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    Tbeta4-ILK complexes then recruit and activate Akt2, resulting in matrix metalloproteinase-2 production.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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