In rat fetuses from irradiated females, maternal triptorelin treatment reduced most cytogenetic instability parameters versus controls, with some significant differences.
In plain wordsIn rat fetuses from irradiated females, maternal triptorelin treatment reduced most cytogenetic instability measures versus controls, with some significant differences.
- Outcome
- DecreaseCytogenetic chromosomal instability parameters
- Study
Rattus norvegicusn: not reported in source
Ovarian X-irradiation- Comparator
- Irradiated controls without triptorelin
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- Dose not stated
Source sentences
The cytogenetical analysis shows a general decrease in most of the parameters of the triptorelin-treated groups, with respect to their controls, and some of these differences were considered to be statistically significant.
3 context sentences(design, population, supporting numbers)
Triptorelin confers radio-protection of the ovaries in front of chromosomal instability, which is different, with respect to the single and fractioned dose.
This has led us to study the possible radio-protection of the ovarian function of a GnRH agonist analogue (GnRHa), triptorelin, in adult, female rats (Rattus norvegicus sp.).
The effects of the X-irradiation on the oocytes of ovarian primordial follicles, with and without GnRHa treatment, were compared, directly in the female rats (F(0)) with reproductive parameters, and in the somatic cells of the resulting foetuses (F(1)) with cytogenetical parameters.