Skip to content

Study · Animal study (in vivo) · 2009

3 results

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides.

Gutiérrez-Pascual E, Leprince J, Martínez-Fuentes AJ, Ségalas-Milazzo I, Pineda R, Roa J, Duran-Prado M, Guilhaudis L, Desperrois E, Lebreton A, Pinilla L, Tonon MC and 4 more

Show all authors

Malagón MM, Vaudry H, Tena-Sempere M, Castaño JP

Molecular pharmacology23 Apr 2009Cited by 49 (Europe PMC)

PMID19389922 (opens in a new tab)DOI10.1124/mol.108.053751 (opens in a new tab)PepBankPUB-19389922
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In vivo, coadministration of the Ala(6) or Ala(10) analog did not affect the LH-releasing ability of kisspeptin‑10.

    In plain wordsIn animals, adding either altered kisspeptin‑10 analog did not change how much LH kisspeptin‑10 released.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH-releasing ability of kp-10 with coadministered Ala-substituted analogs
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas coadministration of each analog failed to affect the LH-releasing ability of kp-10.
    1 context sentence
    Summary · context
    We report herein functional and structural analyses of a series of Ala-substituted rat kp-10 analogs, involving [Ca(2+)](i) responses in rat kiss1r-transfected Chinese hamster ovary cells, dynamic luteinizing hormone (LH) responses in vivo, and NMR structural studies.
  2. 02LabIn vitro (cells)Activity measurement

    In kiss1r-transfected CHO cells, rat and human kisspeptin‑10 had EC50 values of 1.54 to 2.6 x 10(-8) M in calcium responses.

    In plain wordsIn cells, rat and human kisspeptin‑10 activated the kisspeptin receptor at very low concentrations.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableEC50 of rat and human kisspeptin-10 for calcium responses
    Study

    Chinese hamstern: not reported in source

    Rat kiss1r-transfected Chinese hamster ovary cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    EC50
    1.54 to 2.6 x 10(-8) M
    rat and human Kp-10, kiss1r-transfected CHO cells

    Source sentences

    Summary
    1.54 to 2.6 x 10(-8) M for rat and human Kp-10, respectively
    1 context sentence
    Summary · context
    We report herein functional and structural analyses of a series of Ala-substituted rat kp-10 analogs, involving [Ca(2+)](i) responses in rat kiss1r-transfected Chinese hamster ovary cells, dynamic luteinizing hormone (LH) responses in vivo, and NMR structural studies.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 03LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Other

    NMR-restrained molecular modeling showed that kp-10 has a helical structure between Asn(4) and Tyr(10) with mixed alpha- and 3(10)-helix features.

    In plain wordsIn lab tests, modeling showed that kisspeptin‑10 folds into a helix between two of its amino acids.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableStructure of kp-10 by NMR-restrained modeling
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Molecular modeling under NMR restraints revealed that kp-10 exhibits a helicoidal structure between the Asn(4) and Tyr(10) residues, with mixed alpha- and 3(10)-helix characteristics.
    1 context sentence
    Summary · context
    We report herein functional and structural analyses of a series of Ala-substituted rat kp-10 analogs, involving [Ca(2+)](i) responses in rat kiss1r-transfected Chinese hamster ovary cells, dynamic luteinizing hormone (LH) responses in vivo, and NMR structural studies.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.