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Study · Non-randomized trial · n = 11 · 2009

6 results

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.

Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society21 Apr 2009Cited by 26 (Europe PMC)

PMID19386527 (opens in a new tab)PMCIDPMC2787983 (opens in a new tab)DOI10.1016/j.ghir.2009.03.001 (opens in a new tab)PepBankPUB-19386527
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialMechanism

    In healthy young men, one week after CJC‑1295 injection, an apolipoprotein A1 isoform spot in serum showed decreased intensity.

    In plain wordsIn healthy young men, an apolipoprotein A1 form in the blood decreased one week after a CJC‑1295 injection.

    Peptide
    CJC-1295 (with DAC)
    Outcome
    DecreaseSerum apolipoprotein A1 isoform spot intensity
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Two protein spots that displayed decreased intensities after treatment were identified as an apolipoprotein A1 isoform and a transthyretin isoform.
    1 context sentence
    Summary · context
    Sera from 11 healthy young adult men before and one week after CJC-1295 injection were analyzed by two-dimensional gel electrophoresis for proteomic changes.
  2. 02HumanNon-randomized trialMechanism

    In healthy young men, one week after CJC‑1295 injection, a transthyretin isoform spot in serum showed decreased intensity.

    In plain wordsIn healthy young men, a transthyretin form in the blood decreased one week after a CJC‑1295 injection.

    Peptide
    CJC-1295 (with DAC)
    Outcome
    DecreaseSerum transthyretin isoform spot intensity
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Two protein spots that displayed decreased intensities after treatment were identified as an apolipoprotein A1 isoform and a transthyretin isoform.
    1 context sentence
    Summary · context
    Sera from 11 healthy young adult men before and one week after CJC-1295 injection were analyzed by two-dimensional gel electrophoresis for proteomic changes.
  3. 03HumanNon-randomized trialMechanism

    In healthy young men, beta-hemoglobin in serum was upregulated after CJC‑1295 treatment.

    In plain wordsIn healthy young men, beta-hemoglobin in the blood increased after CJC‑1295 treatment.

    Peptide
    CJC-1295 (with DAC)
    Outcome
    IncreaseSerum beta-hemoglobin spot intensity
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Three protein spots upregulated by CJC-1295 treatment included beta-hemoglobin, a C-terminal fragment of albumin, and a mix of an immunoglobulin fragment and another C-terminal albumin fragment.
    1 context sentence
    Summary · context
    Sera from 11 healthy young adult men before and one week after CJC-1295 injection were analyzed by two-dimensional gel electrophoresis for proteomic changes.
  4. 04HumanNon-randomized trialMechanism

    In healthy young men, a C-terminal fragment of albumin in serum was upregulated after CJC‑1295 treatment.

    In plain wordsIn healthy young men, a fragment of albumin in the blood increased after CJC‑1295 treatment.

    Peptide
    CJC-1295 (with DAC)
    Outcome
    IncreaseSerum C-terminal albumin fragment spot intensity
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Three protein spots upregulated by CJC-1295 treatment included beta-hemoglobin, a C-terminal fragment of albumin, and a mix of an immunoglobulin fragment and another C-terminal albumin fragment.
    1 context sentence
    Summary · context
    Sera from 11 healthy young adult men before and one week after CJC-1295 injection were analyzed by two-dimensional gel electrophoresis for proteomic changes.
  5. 05HumanNon-randomized trialMechanism

    In healthy young men, a serum spot containing an immunoglobulin fragment and another C-terminal albumin fragment was upregulated by CJC‑1295 treatment.

    In plain wordsIn healthy young men, a blood protein spot with an immunoglobulin fragment and an albumin fragment increased after CJC‑1295 treatment.

    Peptide
    CJC-1295 (with DAC)
    Outcome
    IncreaseSerum immunoglobulin fragment and albumin fragment mixed spot intensity
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Three protein spots upregulated by CJC-1295 treatment included beta-hemoglobin, a C-terminal fragment of albumin, and a mix of an immunoglobulin fragment and another C-terminal albumin fragment.
    1 context sentence
    Summary · context
    Sera from 11 healthy young adult men before and one week after CJC-1295 injection were analyzed by two-dimensional gel electrophoresis for proteomic changes.
  6. 06HumanNon-randomized trialMechanism

    In healthy young men given CJC‑1295, the serum spot containing immunoglobulin and albumin fragments had a linear relationship with IGF-1 levels.

    In plain wordsIn healthy young men given CJC‑1295, a blood protein spot with immunoglobulin and albumin fragments rose and fell in line with IGF-1 levels.

    Peptide
    CJC-1295 (with DAC)
    Outcome
    Not applicableCorrelation of immunoglobulin and albumin fragment spot with IGF-1 levels
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A linear relationship was found between the spot containing immunoglobulin and albumin fragments and IGF-1 levels.
    2 context sentences
    Summary · context
    In addition, correlations between these proteins and GH or IGF-1 levels were evaluated.
    Summary · context
    Sera from 11 healthy young adult men before and one week after CJC-1295 injection were analyzed by two-dimensional gel electrophoresis for proteomic changes.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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