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Study · Animal study (in vivo) · rat · 2009

6 results

Potencies of centrally- or peripherally-injected full-length kisspeptin or its C-terminal decapeptide on LH release in intact male rats.

Pheng V, Uenoyama Y, Homma T, Inamoto Y, Takase K, Yoshizawa-Kumagaye K, Isaka S, Watanabe TX, Ohkura S, Tomikawa J, Maeda K, Tsukamura H

The Journal of reproduction and development21 Apr 2009Cited by 37 (Europe PMC)

PMID19384054 (opens in a new tab)DOI10.1262/jrd.20240 (opens in a new tab)PepBankPUB-19384054
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular rKp-10 at 0.1 nmol did not increase plasma LH.

    In plain wordsIn male rats, a low dose of rat Kp-10 injected into the brain did not raise blood LH.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma LH after icv rKp-10 0.1 nmol
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.1 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    On the other hand, icv injection of rKp-10 did not increase the plasma LH level at the same dose (0.1 nmol).
    1 context sentence
    Summary · context
    Plasma LH profiles were determined by frequent blood sampling at 6-min intervals for 3 h after central or peripheral injection of kisspeptins.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular rKp-10 at 1 nmol increased plasma LH, but less than rKp-52 did.

    In plain wordsIn male rats, a higher dose of rat Kp-10 injected into the brain raised blood LH, but less than full-length kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after icv rKp-10 1 nmol
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    A 10-times higher dose (1 nmol) of rKp-10 and hKp-10 increased the plasma LH level, but the increase was lower than that of rKp-52 icv injection.
    1 context sentence
    Summary · context
    Plasma LH profiles were determined by frequent blood sampling at 6-min intervals for 3 h after central or peripheral injection of kisspeptins.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intracerebroventricular hKp-10 at 1 nmol increased plasma LH, but less than rKp-52 did.

    In plain wordsIn male rats, a higher dose of human Kp-10 injected into the brain raised blood LH, but less than full-length kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after icv hKp-10 1 nmol
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    A 10-times higher dose (1 nmol) of rKp-10 and hKp-10 increased the plasma LH level, but the increase was lower than that of rKp-52 icv injection.
    1 context sentence
    Summary · context
    Plasma LH profiles were determined by frequent blood sampling at 6-min intervals for 3 h after central or peripheral injection of kisspeptins.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, plasma LH declined more rapidly after its peak at about 30 min with intravenous rKp-10 at 10 and 100 nmol/kg, whereas it stayed high until 60 min with rKp-52 at 10 nmol/kg.

    In plain wordsIn male rats, blood LH fell back faster after rat Kp-10 than after full-length kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableTime course of plasma LH after iv rKp-10
    Study

    ratn: not reported in source

    Comparator
    rKp-52
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 and 100 nmol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    The rKp-10- and hKp-10-injected animals showed a more rapid decline in plasma LH level after the peak found at around 30 min after the injections at both middle (10 nmol/kg) and high (100 nmol/kg) doses.
    2 context sentences
    Summary · context
    In rKp-52 (10 nmol/kg)-treated animals, the plasma LH level reached a peak within 30 min and remained high until 60 min postinjection.
    Summary · context
    Plasma LH profiles were determined by frequent blood sampling at 6-min intervals for 3 h after central or peripheral injection of kisspeptins.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, plasma LH declined more rapidly after its peak at about 30 min with intravenous hKp-10 at 10 and 100 nmol/kg, whereas it stayed high until 60 min with rKp-52 at 10 nmol/kg.

    In plain wordsIn male rats, blood LH fell back faster after human Kp-10 than after full-length kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableTime course of plasma LH after iv hKp-10
    Study

    ratn: not reported in source

    Comparator
    rKp-52
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 and 100 nmol/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    The rKp-10- and hKp-10-injected animals showed a more rapid decline in plasma LH level after the peak found at around 30 min after the injections at both middle (10 nmol/kg) and high (100 nmol/kg) doses.
    2 context sentences
    Summary · context
    In rKp-52 (10 nmol/kg)-treated animals, the plasma LH level reached a peak within 30 min and remained high until 60 min postinjection.
    Summary · context
    Plasma LH profiles were determined by frequent blood sampling at 6-min intervals for 3 h after central or peripheral injection of kisspeptins.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 06AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In male rats, intravenous injection of kisspeptins (full-length and Kp-10 forms pooled) stimulated LH release at 10 or 100 nmol/kg.

    In plain wordsIn male rats, injected kisspeptins of different lengths raised blood LH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after intravenous kisspeptins (pooled)
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Intravenous (iv) injection of kisspeptins also stimulated LH release at 10 or 100 nmol/kg.
    1 context sentence
    Summary · context
    Plasma LH profiles were determined by frequent blood sampling at 6-min intervals for 3 h after central or peripheral injection of kisspeptins.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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