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Study · In vitro (cells) · mouse · 2009

2 results

Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils.

Bulgarelli I, Tamiazzo L, Bresciani E, Rapetti D, Caporali S, Lattuada D, Locatelli V, Torsello A

Journal of neuroscience research1 Sept 2009Cited by 65 (Europe PMC)

PMID19382238 (opens in a new tab)DOI10.1002/jnr.22088 (opens in a new tab)PepBankPUB-19382238
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mouse N9 microglia cells, hexarelin counteracted the fAbeta(25-35)-induced increase in IL-6 mRNA levels.

    In plain wordsIn mouse microglia cells, hexarelin reduced the rise in an inflammation signal (IL-6 mRNA) caused by beta-amyloid fibrils.

    Peptide
    Hexarelin
    Outcome
    DecreaseIL-6 mRNA level after fAbeta(25-35) stimulation
    Study

    mousen: not reported in source

    N9 microglia cells stimulated with fAbeta(25-35)
    Comparator
    fAbeta(25-35) stimulation without hexarelin
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, 10(-7) M desacyl-ghrelin, hexarelin, and EP80317 in the nanomolar range effectively counteracted fAbeta(25-35) stimulation of IL-6 mRNA levels, whereas ghrelin was ineffective.
    1 context sentence
    Summary · context
    In fact, in N9 cells exposed to fAbeta(25-35) for 24 hr, the expression of interleukin (IL)-1beta and IL-6 mRNA significantly increased.
  2. 02LabIn vitro (cells)Mechanism

    In mouse N9 microglia cells, hexarelin attenuated the fAbeta(25-35)-induced increase in IL-1beta mRNA levels.

    In plain wordsIn mouse microglia cells, hexarelin reduced the rise in an inflammation signal (IL-1beta mRNA) caused by beta-amyloid fibrils.

    Peptide
    Hexarelin
    Outcome
    DecreaseIL-1beta mRNA level after fAbeta(25-35) stimulation
    Study

    mousen: not reported in source

    N9 microglia cells stimulated with fAbeta(25-35)
    Comparator
    fAbeta(25-35) stimulation without hexarelin
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similarly, the effects of fAbeta(25-35) on IL-1beta mRNA levels were attenuated by desacyl-ghrelin, hexarelin, and EP80317, but not ghrelin.
    1 context sentence
    Summary · context
    In fact, in N9 cells exposed to fAbeta(25-35) for 24 hr, the expression of interleukin (IL)-1beta and IL-6 mRNA significantly increased.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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