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Study · In vitro (cell-free) · 2009

4 results

Humanin structural versatility and interaction with model cerebral cortex membranes.

Pistolesi S, Rossini L, Ferro E, Basosi R, Trabalzini L, Pogni R

Biochemistry1 Jun 2009Cited by 13 (Europe PMC)

PMID19378954 (opens in a new tab)DOI10.1021/bi900187s (opens in a new tab)PepBankPUB-19378954
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    HN slightly perturbed model cerebral cortex membranes at the surface.

    In plain wordsIn lab tests, humanin slightly disturbed the surface of model brain membranes.

    Peptide
    Humanin
    Outcome
    Not applicablePerturbation of model cerebral cortex membranes
    Study

    n: not reported in source

    Solution and model cerebral cortex membranes (EPR, CD)
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that HN slightly perturbs model CCM at the surface
  2. 02LabIn vitro (cell-free)Mechanism

    HN increased the fluidity of the bilayer core of model cerebral cortex membranes without penetrating into the membrane.

    In plain wordsIn lab tests, humanin made the core of model brain membranes more fluid without entering the membrane.

    Peptide
    Humanin
    Outcome
    IncreaseFluidity of the bilayer core
    Study

    n: not reported in source

    Solution and model cerebral cortex membranes (EPR, CD)
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HN increases the fluidity of the bilayer core without penetrating into the membrane.

Studies that did not test the peptide alone2

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 03LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    In water solutions at different ionic strengths, HN had a great tendency to aggregate even at low concentrations and monomerized in the apolar TFE environment.

    In plain wordsIn lab tests, humanin clumped together even at low concentrations in water and separated into single peptides in TFE.

    Peptide
    Humanin
    Outcome
    Not applicableAggregation and monomerization of HN in solution
    Study

    n: not reported in source

    Solution and model cerebral cortex membranes (EPR, CD)
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We have demonstrated that HN has a great tendency to aggregate even at low concentrations in water solutions at different ionic strengths and monomerizes in the TFE apolar environment.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 04LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    In the presence of model cerebral cortex membranes, HN assumed a clear beta-sheet conformation.

    In plain wordsIn lab tests, humanin took a beta-sheet shape when model brain membranes were present.

    Peptide
    Humanin
    Outcome
    Not applicableHN conformation with model membranes
    Study

    n: not reported in source

    Solution and model cerebral cortex membranes (EPR, CD)
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    assuming a clear beta-sheet conformation.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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