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Study · In vitro (cells) · 2009

3 results

[Effects of humanin on elevation of intracellular calcium concentration induced by beta-amyloid peptide(31-35) in cultured cortical neurons.].

Li LM, Qiao JT, Zhang C

Sheng li xue bao : [Acta physiologica Sinica]1 Apr 2009Cited by 2 (Europe PMC)

PMID19377823 (opens in a new tab)PepBankPUB-19377823
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured cortical neurons, pretreatment with 10 µmol/L humanin for 10 min significantly decreased the rise in intracellular calcium that Abeta(31-35) caused.

    In plain wordsIn cells, humanin given before the amyloid fragment lowered the calcium rise in brain cells.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta(31-35)-induced rise in intracellular calcium, 10 µmol/L HN pretreatment
    Study

    n = 10

    Cultured cortical neurons with Abeta(31-35) 25 µmol/L
    Comparator
    Abeta(31-35) alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 µmol/L · 10 min pretreatmentAs given in this study.

    Source sentences

    Summary
    Pretreatment of HN (10 mumol/L) for 10 min significantly decreased the elevation of [Ca(2+)](i) induced by Abeta(31-35) (25 mumol/L) (F340/F380: 918.788+/- 50.73, compared with Abeta(31-35) group, P<0.05, n=10).
    1 context sentence
    Summary · context
    The present study was to investigate the effects of HN on Abeta(31-35)-induced elevation of [Ca(2+)](i) in cultured cortical neurons by real-time fluorescence imaging technique using the Ca(2+)-sensitive dye, Fura-2/AM.
  2. 02LabIn vitro (cells)Mechanism

    In cultured cortical neurons, 10 µmol/L humanin given at the same time as Abeta(31-35) did not change the rise in intracellular calcium.

    In plain wordsIn cells, humanin at 10 µmol/L given at the same time as the amyloid fragment did not change the calcium rise.

    Peptide
    Humanin
    Outcome
    No significant changeAbeta(31-35)-induced rise in intracellular calcium, 10 µmol/L HN given with Abeta
    Study

    n = 10

    Cultured cortical neurons with Abeta(31-35) 25 µmol/L
    Comparator
    Abeta(31-35) alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 µmol/LAs given in this study.

    Source sentences

    Summary
    When neurons were treated with HN and Abeta(31-35) simultaneously, HN (10 mumol/L) could not change the elevation of [Ca(2+)](i) induced by Abeta(31-35) (F340/F380: 1 036.68+/- 88.96, compared with Abeta(31-35) group, P>0.05, n=10)
    1 context sentence
    Summary · context
    The present study was to investigate the effects of HN on Abeta(31-35)-induced elevation of [Ca(2+)](i) in cultured cortical neurons by real-time fluorescence imaging technique using the Ca(2+)-sensitive dye, Fura-2/AM.
  3. 03LabIn vitro (cells)Mechanism

    In cultured cortical neurons, 20 µmol/L humanin given at the same time as Abeta(31-35) significantly diminished the rise in intracellular calcium.

    In plain wordsIn cells, humanin at 20 µmol/L given at the same time as the amyloid fragment lowered the calcium rise in brain cells.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta(31-35)-induced rise in intracellular calcium, 20 µmol/L HN given with Abeta
    Study

    n = 10

    Cultured cortical neurons with Abeta(31-35) 25 µmol/L
    Comparator
    Abeta(31-35) alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 µmol/LAs given in this study.

    Source sentences

    Summary
    while HN (20 mumol/L) diminished the elevation of [Ca(2+)](i) induced by Abeta(31-35) (25 mumol/L) significantly (F340/F380: 898.56+/- 76.46, compared with Abeta(31-35) group, P<0.05, n=10).
    1 context sentence
    Summary · context
    The present study was to investigate the effects of HN on Abeta(31-35)-induced elevation of [Ca(2+)](i) in cultured cortical neurons by real-time fluorescence imaging technique using the Ca(2+)-sensitive dye, Fura-2/AM.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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