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Study · Not a test of the peptide alone · 2009

4 results

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.

Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Mar 2009Cited by 257 (Europe PMC)

PMID19321788 (opens in a new tab)PMCIDPMC3035813 (opens in a new tab)DOI10.1523/jneurosci.5740-08.2009 (opens in a new tab)PepBankPUB-19321788
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Activity measurement

    In mice, a selected kisspeptin‑10 analogue antagonist inhibited the firing of GnRH neurons in the brain.

    In plain wordsIn mice, a modified kisspeptin‑10 blocker reduced the firing of reproductive-control brain cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseFiring of GnRH neurons
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    A selected antagonist was shown to inhibit the firing of GnRH neurons in the brain of the mouse
    1 context sentence
    Summary · context
    In vitro and in vivo studies of analogues of kisspeptin-10 with amino substitutions have identified several potent and specific antagonists.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Activity measurement

    In female pubertal monkeys, a selected kisspeptin‑10 analogue antagonist reduced pulsatile GnRH secretion.

    In plain wordsIn young female monkeys, a modified kisspeptin‑10 blocker reduced pulses of GnRH release.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePulsatile GnRH secretion in pubertal monkeys
    Study

    monkeyn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    reduce pulsatile GnRH secretion in female pubertal monkeys; the later supporting a key role of kisspeptin in puberty onset.
    1 context sentence
    Summary · context
    In vitro and in vivo studies of analogues of kisspeptin-10 with amino substitutions have identified several potent and specific antagonists.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Activity measurement

    In rats and mice, the kisspeptin‑10 analogue antagonist inhibited kisspeptin-induced release of luteinizing hormone.

    In plain wordsIn rats and mice, a modified kisspeptin‑10 blocker reduced luteinizing hormone release caused by kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKisspeptin-induced LH release
    Study

    rat, mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    This analog also inhibited the kisspeptin-induced release of luteinizing hormone (LH) in rats and mice
    1 context sentence
    Summary · context
    In vitro and in vivo studies of analogues of kisspeptin-10 with amino substitutions have identified several potent and specific antagonists.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  4. 04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Activity measurement

    In sheep, rats and mice, the kisspeptin‑10 analogue antagonist blocked the postcastration rise in luteinizing hormone.

    In plain wordsIn sheep, rats and mice, a modified kisspeptin‑10 blocker prevented the rise in luteinizing hormone after castration.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePostcastration rise in LH
    Study

    sheep, rat, mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    blocked the postcastration rise in LH in sheep, rats, and mice
    1 context sentence
    Summary · context
    In vitro and in vivo studies of analogues of kisspeptin-10 with amino substitutions have identified several potent and specific antagonists.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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