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Study · Not a test of the peptide alone · 2009

2 results

Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution.

Shin R, Welch DR, Mishra VK, Nash KT, Hurst DR, Rama Krishna N

Clinical & experimental metastasis24 Mar 2009Cited by 5 (Europe PMC)

PMID19308666 (opens in a new tab)PMCIDPMC2756240 (opens in a new tab)DOI10.1007/s10585-009-9252-0 (opens in a new tab)PepBankPUB-19308666
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

  1. 01LabNot a test of Kisspeptin-54 (metastin) aloneIn vitro (cell-free)Mechanism

    In water and in trifluoroethanol/water mixed solvent, kisspeptin‑54 is mostly disordered with no structural motifs.

    In plain wordsIn lab tests, kisspeptin‑54 had little fixed shape in water and in a water and alcohol mix.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableSecondary structure of KP-54 in water and trifluoroethanol/water
    Study

    n: not reported in source

    In solution (NMR and circular dichroism)
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    KP-54 is mostly disordered both in water and in trifluoroethanol/water mixed solvent, with no structural motifs.
    1 context sentence
    Summary · context
    The current studies were undertaken in order to determine structure of KP-54 using nuclear magnetic resonance and circular dichroism.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

  2. 02LabNot a test of Kisspeptin-54 (metastin) aloneIn vitro (cell-free)Mechanism

    In sodium dodecyl sulfate micelles, kisspeptin‑54 stays mostly disordered, with a small rise in helical propensity compared with water.

    In plain wordsIn lab tests, kisspeptin‑54 stayed mostly unstructured in soap-like micelles, with a small rise in helical shape.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseHelical propensity of KP-54 in SDS micelles
    Study

    n: not reported in source

    In solution (NMR and circular dichroism)
    Comparator
    Water
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Helical propensity
    3.7%
    water
    Helical propensity
    9.9%
    SDS micelles

    Source sentences

    Summary
    In sodium dodecyl sulfate micelles, KP-54 remains mostly disordered except for a small increase in helical propensity (from 3.7% in water to 9.9% in micelles).
    1 context sentence
    Summary · context
    The current studies were undertaken in order to determine structure of KP-54 using nuclear magnetic resonance and circular dichroism.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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