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Study · Animal study (in vivo) · goldfish · 2009

7 results

Structural and functional multiplicity of the kisspeptin/GPR54 system in goldfish (Carassius auratus).

Li S, Zhang Y, Liu Y, Huang X, Huang W, Lu D, Zhu P, Shi Y, Cheng CH, Liu X, Lin H

The Journal of endocrinology20 Mar 2009Cited by 157 (Europe PMC)

PMID19304758 (opens in a new tab)DOI10.1677/joe-09-0016 (opens in a new tab)PepBankPUB-19304758
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sexually mature female goldfish, intraperitoneal gfKiss1-10 could increase serum LH levels.

    In plain wordsIn female goldfish, an injected goldfish kisspeptin‑10 peptide could raise LH in the blood.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum LH after intraperitoneal gfKiss1-10
    Study

    goldfishn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intraperitonealAs given in this study (goldfish).

    Source sentences

    Summary
    Intraperitoneal administration of gfKiss1-10 to sexually mature female goldfish could increase the serum LH levels.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In goldfish, gfKiss2-10 showed no significant in vivo bioactivity and was a much less potent peptide.

    In plain wordsIn goldfish, the Kiss2-10 peptide showed no significant effect in the living animal.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeIn vivo bioactivity of gfKiss2-10
    Study

    goldfishn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, gfKiss2-10 appears to be a much less potent peptide as it exhibits no significant in vivo bioactivity and is also inactive on the primary pituitary cells.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured eukaryotic cells expressing the two goldfish receptors, both gfKiss1-10 and gfKiss2-10 were biologically active and triggered downstream signaling with different potencies.

    In plain wordsIn cells, both goldfish kisspeptin‑10 peptides activated the two goldfish receptors, but with different strength.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableActivation of goldfish receptors by gfKiss1-10 and gfKiss2-10
    Study

    n: not reported in source

    cultured eukaryotic cells expressing goldfish receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both mature goldfish kisspeptin-10 peptides (gfKiss1-10 and gfKiss2-10) are biologically active as they could functionally interact with the two goldfish receptors expressed in cultured eukaryotic cells to trigger the downstream signaling pathways with different potencies.
  4. 04LabIn vitro (cells)Efficacy outcome

    In primary cultures of goldfish pituitary cells, gfKiss1-10 did not significantly influence LH release.

    In plain wordsIn goldfish pituitary cells, this kisspeptin‑10 peptide did not change LH release significantly.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH release from pituitary cells with gfKiss1-10
    Study

    goldfishn: not reported in source

    primary culture of goldfish pituitary cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, this peptide does not significantly influence LH release from goldfish pituitary cells in primary culture, indicating that the peptide does not exert its actions at the pituitary level.
  5. 05LabIn vitro (cells)Efficacy outcome

    In primary goldfish pituitary cells, gfKiss2-10 was inactive.

    In plain wordsIn goldfish pituitary cells, the Kiss2-10 peptide had no activity.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePituitary cell response to gfKiss2-10
    Study

    goldfishn: not reported in source

    primary culture of goldfish pituitary cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, gfKiss2-10 appears to be a much less potent peptide as it exhibits no significant in vivo bioactivity and is also inactive on the primary pituitary cells.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 06AnimalEndogenous levelAnimal study (in vivo)Other

    In goldfish, kiss1 was highly expressed in the optic tectum-thalamus, intestine, kidney, and testis.

    In plain wordsIn goldfish, the body's own kiss1 gene was most active in the optic tectum-thalamus, intestine, kidney and testis.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicablekiss1 gene expression across goldfish tissues
    Study

    goldfishn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    RT-PCR analysis demonstrated that the goldfish kiss1 gene (gfkiss1) is highly expressed in the optic tectum-thalamus, intestine, kidney, and testis, while the goldfish kiss2 gene (gfkiss2) is mainly detected in the hypothalamus, telencephalon, optic tectum thalamus, adipose tissue, kidney, heart, and gonads.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 07AnimalEndogenous levelAnimal study (in vivo)Other

    In goldfish, kiss2 was mainly detected in the hypothalamus, telencephalon, optic tectum thalamus, adipose tissue, kidney, heart, and gonads.

    In plain wordsIn goldfish, the body's own kiss2 gene was mainly found in brain regions, fat, kidney, heart and gonads.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicablekiss2 gene expression across goldfish tissues
    Study

    goldfishn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    RT-PCR analysis demonstrated that the goldfish kiss1 gene (gfkiss1) is highly expressed in the optic tectum-thalamus, intestine, kidney, and testis, while the goldfish kiss2 gene (gfkiss2) is mainly detected in the hypothalamus, telencephalon, optic tectum thalamus, adipose tissue, kidney, heart, and gonads.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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