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Study · Observational study · n = 62 · 2009

6 results

Leiomyoma pseudocapsule after pre-surgical treatment with gonadotropin-releasing hormone agonists: relationship between clinical features and immunohistochemical changes.

De Falco M, Staibano S, Mascolo M, Mignogna C, Improda L, Ciociola F, Carbone IF, Di Lieto A

European journal of obstetrics, gynecology, and reproductive biology17 Mar 2009Cited by 46 (Europe PMC)

PMID19297072 (opens in a new tab)DOI10.1016/j.ejogrb.2009.02.006 (opens in a new tab)PepBankPUB-19297072
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In patients undergoing myomectomy, those pretreated with triptorelin depot had lower blood loss than untreated controls.

    In plain wordsIn myoma surgery, earlier triptorelin treatment was linked to less blood loss than in untreated patients.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseIntraoperative blood loss
    Study

    n = 62

    Comparator
    Untreated patients
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treated patients showed lower blood loss and not clearly identifiable cleavage plan, but without any significant increase in the operating time.
    2 context sentences
    Summary · context
    The study was performed at the University Federico II of Naples on 33 premenopausal patients submitted to laparotomic myomectomy after treatment with triptorelin depot.
    Summary · context
    29 untreated patients formed the control group.
  2. 02HumanObservational studyEfficacy outcome

    In patients undergoing myomectomy, the cleavage plane was less clearly identifiable after triptorelin pretreatment than in untreated patients.

    In plain wordsIn myoma surgery, earlier triptorelin treatment was linked to a cleavage plane that was harder to identify than in untreated patients.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseCleavage plane identification
    Study

    n = 62

    Comparator
    Untreated patients
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treated patients showed lower blood loss and not clearly identifiable cleavage plan, but without any significant increase in the operating time.
    2 context sentences
    Summary · context
    The study was performed at the University Federico II of Naples on 33 premenopausal patients submitted to laparotomic myomectomy after treatment with triptorelin depot.
    Summary · context
    29 untreated patients formed the control group.
  3. 03HumanObservational studyEfficacy outcome

    In patients undergoing myomectomy, preoperative triptorelin did not significantly increase operating time versus untreated controls.

    In plain wordsIn patients undergoing myomectomy, preoperative triptorelin did not significantly increase operating time versus untreated controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOperating time
    Study

    n = 62

    Comparator
    Untreated patients
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treated patients showed lower blood loss and not clearly identifiable cleavage plan, but without any significant increase in the operating time.
    2 context sentences
    Summary · context
    The study was performed at the University Federico II of Naples on 33 premenopausal patients submitted to laparotomic myomectomy after treatment with triptorelin depot.
    Summary · context
    29 untreated patients formed the control group.
  4. 04HumanObservational studyEfficacy outcome

    Triptorelin-treated leiomyomas had less evident borders with the myometrium than untreated lesions.

    In plain wordsTriptorelin-treated leiomyomas had less evident borders with the myometrium than untreated lesions.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseMyoma-myometrium border visibility
    Study

    n = 62

    Comparator
    Untreated patients
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treated lesions showed less evident border between myoma and myometrium and lower PCNA and CD34 pseudocapsule immunoexpression than untreated ones.
    2 context sentences
    Summary · context
    The study was performed at the University Federico II of Naples on 33 premenopausal patients submitted to laparotomic myomectomy after treatment with triptorelin depot.
    Summary · context
    29 untreated patients formed the control group.
  5. 05HumanObservational studyMechanism

    Triptorelin-treated leiomyomas had lower pseudocapsule PCNA immunoexpression than untreated lesions.

    In plain wordsTriptorelin-treated leiomyomas had lower pseudocapsule PCNA immunoexpression than untreated lesions.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePseudocapsule PCNA immunoexpression
    Study

    n = 62

    Comparator
    Untreated patients
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treated lesions showed less evident border between myoma and myometrium and lower PCNA and CD34 pseudocapsule immunoexpression than untreated ones.
    2 context sentences
    Summary · context
    The study was performed at the University Federico II of Naples on 33 premenopausal patients submitted to laparotomic myomectomy after treatment with triptorelin depot.
    Summary · context
    29 untreated patients formed the control group.
  6. 06HumanObservational studyMechanism

    Triptorelin-treated leiomyomas had lower pseudocapsule CD34 immunoexpression than untreated lesions.

    In plain wordsTriptorelin-treated leiomyomas had lower pseudocapsule CD34 immunoexpression than untreated lesions.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePseudocapsule CD34 immunoexpression
    Study

    n = 62

    Comparator
    Untreated patients
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treated lesions showed less evident border between myoma and myometrium and lower PCNA and CD34 pseudocapsule immunoexpression than untreated ones.
    2 context sentences
    Summary · context
    The study was performed at the University Federico II of Naples on 33 premenopausal patients submitted to laparotomic myomectomy after treatment with triptorelin depot.
    Summary · context
    29 untreated patients formed the control group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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