Clinical study shows improved absorption of desmopressin with novel formulation.

Fransén N, Bredenberg S, Björk E

Pharmaceutical research19 Mar 2009Cited by 24 (Europe PMC)

PMID19296208DOI10.1007/s11095-009-9871-9PepBankPUB-19296208

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Desmopressin.

01HumanNot a test of Desmopressin aloneRandomized controlled trialPharmacokinetics
In healthy volunteers, desmopressin nasal powder increased absorption threefold compared with liquid spray.
In plain wordsIn healthy volunteers, desmopressin nasal powder increased absorption threefold compared with liquid spray.
Peptide
Desmopressin
Outcome
IncreaseNasal absorption
Study
n: not reported in source
Comparator
Commercial nasal liquid spray
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Absorption increase
3 fold
nasal powder vs commercial liquid spray
Source sentences
Summary
The nasal powder formulation gave a threefold increase in the absorption, unaltered time to maximum plasma concentration and a tendency to lower variability in the amount absorbed compared with the liquid spray.
1 context sentence(design, population, supporting numbers)
Summary · context
The clinical study was an open-label, randomised cross-over pharmacokinetic study in healthy volunteers.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1929620801
02HumanNot a test of Desmopressin aloneRandomized controlled trialPharmacokinetics
In healthy volunteers, desmopressin nasal powder did not alter time to maximum plasma concentration compared with liquid spray.
In plain wordsIn healthy volunteers, desmopressin nasal powder did not change time to peak blood concentration compared with liquid spray.
Peptide
Desmopressin
Outcome
Direction not reportedTime to maximum plasma concentration
Study
n: not reported in source
Comparator
Commercial nasal liquid spray
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The nasal powder formulation gave a threefold increase in the absorption, unaltered time to maximum plasma concentration and a tendency to lower variability in the amount absorbed compared with the liquid spray.
1 context sentence(design, population, supporting numbers)
Summary · context
The clinical study was an open-label, randomised cross-over pharmacokinetic study in healthy volunteers.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1929620802
03HumanNot a test of Desmopressin aloneRandomized controlled trialPharmacokinetics
In healthy volunteers, desmopressin nasal powder tended to reduce variability in absorption compared with liquid spray.
In plain wordsIn healthy volunteers, desmopressin nasal powder tended to reduce absorption variability compared with liquid spray.
Peptide
Desmopressin
Outcome
DecreaseAbsorption variability
Study
n: not reported in source
Comparator
Commercial nasal liquid spray
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The nasal powder formulation gave a threefold increase in the absorption, unaltered time to maximum plasma concentration and a tendency to lower variability in the amount absorbed compared with the liquid spray.
1 context sentence(design, population, supporting numbers)
Summary · context
The clinical study was an open-label, randomised cross-over pharmacokinetic study in healthy volunteers.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1929620803
04HumanNot a test of Desmopressin aloneRandomized controlled trialSafety outcome
In healthy volunteers, desmopressin nasal powder was more irritating than liquid spray.
In plain wordsIn healthy volunteers, desmopressin nasal powder caused more irritation than liquid spray.
Peptide
Desmopressin
Outcome
IncreaseIrritation
Study
n: not reported in source
Comparator
Commercial nasal liquid spray
Outcome group
Adverse events · Pharmacology
Source sentences
Summary
The powder was reported to be more irritating than the liquid but was still well accepted by the volunteers.
1 context sentence(design, population, supporting numbers)
Summary · context
The clinical study was an open-label, randomised cross-over pharmacokinetic study in healthy volunteers.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1929620804
05HumanNot a test of Desmopressin aloneRandomized controlled trialPharmacokinetics
In healthy volunteers, the sublingual desmopressin tablet did not improve uptake.
In plain wordsIn healthy volunteers, the sublingual desmopressin tablet did not improve absorption compared with commercial nasal liquid spray.
Peptide
Desmopressin
Outcome
Direction not reportedSublingual uptake
Study
n: not reported in source
Comparator
Commercial nasal liquid spray
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The tablet did not improve the uptake of desmopressin, likely because of a poor disintegration sublingually.
1 context sentence(design, population, supporting numbers)
Summary · context
The clinical study was an open-label, randomised cross-over pharmacokinetic study in healthy volunteers.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1929620806
06HumanNot a test of Desmopressin aloneNon-randomized trialOther
Healthy volunteers still accepted the desmopressin nasal powder well.
In plain wordsHealthy volunteers still accepted the desmopressin nasal powder well.
Peptide
Desmopressin
Outcome
Not applicableAcceptability
Study
n: not reported in source
Outcome group
Treatment Acceptability · Pharmacology
Source sentences
Summary
The powder was reported to be more irritating than the liquid but was still well accepted by the volunteers.
1 context sentence(design, population, supporting numbers)
Summary · context
The clinical study was an open-label, randomised cross-over pharmacokinetic study in healthy volunteers.
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-1929620805

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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