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Study · Animal study (in vivo) · rat · 2009

11 results

Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus.

Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B

The Journal of pharmacology and experimental therapeutics16 Mar 2009Cited by 24 (Europe PMC)

PMID19289567 (opens in a new tab)DOI10.1124/jpet.108.149211 (opens in a new tab)PepBankPUB-19289567
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after laparotomy, a single dose of ipamorelin shortened the time to first bowel movement versus vehicle.

    In plain wordsIn rats after abdominal surgery, one dose of ipamorelin shortened the time to the first bowel movement compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    DecreaseTime to first bowel movement, single dose
    Study

    ratn: not reported in source

    Comparator
    Vehicle (saline)
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    1 mg/kg · intravenous bolus infusion · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement but had no effect on cumulative fecal output, food intake, or body weight gain measured 48 h after the surgery.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after laparotomy, a single dose of ipamorelin did not change cumulative fecal output over 48 h versus vehicle.

    In plain wordsIn rats after abdominal surgery, one dose of ipamorelin did not change total fecal output compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    No significant changeCumulative fecal output, single dose
    Study

    ratn: not reported in source

    Comparator
    Vehicle (saline)
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    1 mg/kg · intravenous bolus infusion · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement but had no effect on cumulative fecal output, food intake, or body weight gain measured 48 h after the surgery.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after laparotomy, a single dose of ipamorelin did not change food intake over 48 h versus vehicle.

    In plain wordsIn rats after abdominal surgery, one dose of ipamorelin did not change food intake compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    No significant changeFood intake, single dose
    Study

    ratn: not reported in source

    Comparator
    Vehicle (saline)
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 mg/kg · intravenous bolus infusion · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement but had no effect on cumulative fecal output, food intake, or body weight gain measured 48 h after the surgery.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after laparotomy, a single dose of ipamorelin did not change body weight gain over 48 h versus vehicle.

    In plain wordsIn rats after abdominal surgery, one dose of ipamorelin did not change weight gain compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    No significant changeBody weight gain, single dose
    Study

    ratn: not reported in source

    Comparator
    Vehicle (saline)
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 mg/kg · intravenous bolus infusion · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement but had no effect on cumulative fecal output, food intake, or body weight gain measured 48 h after the surgery.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats after laparotomy, repeated dosing of ipamorelin increased cumulative fecal pellet output versus vehicle.

    In plain wordsIn rats after abdominal surgery, repeated doses of ipamorelin increased total fecal output compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    IncreaseCumulative fecal pellet output, repetitive dosing
    Study

    ratn: not reported in source

    Comparator
    Vehicle (saline)
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.1 or 1 mg/kg · intravenous bolus infusion · 2-day repetitive dosing regimenAs given in this study (rat).

    Source sentences

    Summary
    In contrast, repetitive dosing of ipamorelin (0.1 or 1 mg/kg) significantly increased the cumulative fecal pellet output, food intake, and body weight gain.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats after laparotomy, repeated dosing of ipamorelin increased food intake versus vehicle.

    In plain wordsIn rats after abdominal surgery, repeated doses of ipamorelin increased food intake compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    IncreaseFood intake, repetitive dosing
    Study

    ratn: not reported in source

    Comparator
    Vehicle (saline)
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1 or 1 mg/kg · intravenous bolus infusion · 2-day repetitive dosing regimenAs given in this study (rat).

    Source sentences

    Summary
    In contrast, repetitive dosing of ipamorelin (0.1 or 1 mg/kg) significantly increased the cumulative fecal pellet output, food intake, and body weight gain.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats after laparotomy, repeated dosing of ipamorelin increased body weight gain versus vehicle.

    In plain wordsIn rats after abdominal surgery, repeated doses of ipamorelin increased weight gain compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    IncreaseBody weight gain, repetitive dosing
    Study

    ratn: not reported in source

    Comparator
    Vehicle (saline)
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.1 or 1 mg/kg · intravenous bolus infusion · 2-day repetitive dosing regimenAs given in this study (rat).

    Source sentences

    Summary
    In contrast, repetitive dosing of ipamorelin (0.1 or 1 mg/kg) significantly increased the cumulative fecal pellet output, food intake, and body weight gain.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with postoperative ileus, a single dose of GHRP‑6 shortened the time to the first bowel movement compared with vehicle.

    In plain wordsIn rats after surgery, a single dose of GHRP‑6 shortened the time to the first bowel movement compared with saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseTime to first bowel movement
    Study

    ratn: not reported in source

    postoperative ileus (laparotomy and intestinal manipulation)
    Comparator
    Vehicle (saline)
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    20 µg/kg · intravenous bolus · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with postoperative ileus, a single dose of GHRP‑6 did not change cumulative fecal output compared with vehicle.

    In plain wordsIn rats after surgery, a single dose of GHRP‑6 did not change total fecal output compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeCumulative fecal pellet output at 48 h
    Study

    ratn: not reported in source

    postoperative ileus (laparotomy and intestinal manipulation)
    Comparator
    Vehicle (saline)
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    20 µg/kg · intravenous bolus · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement but had no effect on cumulative fecal output, food intake, or body weight gain measured 48 h after the surgery.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with postoperative ileus, a single dose of GHRP‑6 did not change food intake compared with vehicle.

    In plain wordsIn rats after surgery, a single dose of GHRP‑6 did not change food intake compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeFood intake at 48 h
    Study

    ratn: not reported in source

    postoperative ileus (laparotomy and intestinal manipulation)
    Comparator
    Vehicle (saline)
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    20 µg/kg · intravenous bolus · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement but had no effect on cumulative fecal output, food intake, or body weight gain measured 48 h after the surgery.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats with postoperative ileus, a single dose of GHRP‑6 did not change body weight gain compared with vehicle.

    In plain wordsIn rats after surgery, a single dose of GHRP‑6 did not change weight gain compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeBody weight gain at 48 h
    Study

    ratn: not reported in source

    postoperative ileus (laparotomy and intestinal manipulation)
    Comparator
    Vehicle (saline)
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    20 µg/kg · intravenous bolus · single doseAs given in this study (rat).

    Source sentences

    Summary
    Compared with the vehicle, a single dose of ipamorelin (1 mg/kg) or GHRP-6 (20 microg/kg) decreased the time to the first bowel movement but had no effect on cumulative fecal output, food intake, or body weight gain measured 48 h after the surgery.
    2 context sentences
    Summary · context
    Fasted male rats were subjected to laparotomy and intestinal manipulation.
    Summary · context
    Ipamorelin (0.01-1 mg/kg), growth hormone-releasing peptide (GHRP)-6 (20 microg/kg), or vehicle (saline) were administered via intravenous bolus infusion after a single dosing or a 2-day repetitive dosing regimen (four doses a day at 3-h intervals).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 36Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 34 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:13 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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