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Study · Not a test of the peptide alone · 2009

3 results

Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis.

Navenot JM, Fujii N, Peiper SC

Molecular pharmacology13 Mar 2009Cited by 41 (Europe PMC)

PMID19286835 (opens in a new tab)DOI10.1124/mol.109.055095 (opens in a new tab)PepBankPUB-19286835
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In cell lines, activation of GPR54 by the KiSS1 gene product induced changes of cell morphology, including cytoplasmic condensation and membrane protrusions.

    In plain wordsIn cells, activating the kisspeptin receptor changed cell shape. The activating compound is not named in the abstract.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableCell morphology change after GPR54 activation
    Study

    n: not reported in source

    cell lines (293 cells)
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Title
    Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis.
    1 context sentence
    Summary · context
    We show here that the activation of GPR54 induced immediate and profound changes of cell morphology, including cytoplasmic condensation and formation of unpolarized plasma membrane protrusions.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In cell lines, the morphology changes after GPR54 activation depended on Rho and Rho-associated kinase activation.

    In plain wordsIn cells, shape changes after kisspeptin receptor activation depended on the proteins Rho and ROCK.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableRho and ROCK dependence of morphology changes
    Study

    n: not reported in source

    cell lines (293 cells)
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Title
    Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis.
    1 context sentence
    Summary · context
    These events were dependent on Rho and Rho-Associated Kinase (ROCK) activation.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In 293 cells, ROCK activation contributed to GPR54-mediated apoptosis, additively to and independently of ERK activation.

    In plain wordsIn cells, the ROCK protein helped drive cell death after kisspeptin receptor activation, in addition to ERK.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseROCK contribution to GPR54-mediated apoptosis
    Study

    n: not reported in source

    cell lines (293 cells)
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Title
    Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis.
    1 context sentence
    Summary · context
    The activation of ROCK also contributed to GPR54-mediated apoptosis in 293 cells, and its effect was additive to and independent of ERK activation.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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