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Study · Not a test of the peptide alone · 2009

4 results

Molecular interaction between kisspeptin decapeptide analogs and a lipid membrane.

Lee JY, Moon JS, Eu YJ, Lee CW, Yang ST, Lee SK, Jung HH, Kim HH, Rhim H, Seong JY, Kim JI

Archives of biochemistry and biophysics9 Mar 2009Cited by 9 (Europe PMC)

PMID19275876 (opens in a new tab)DOI10.1016/j.abb.2009.03.002 (opens in a new tab)PepBankPUB-19275876
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Mechanism

    In membrane-mimetic medium, kisspeptin‑10 analogs showed a close correlation between lipid membrane binding and GPR54 agonist activity.

    In plain wordsIn lab tests, kisspeptin‑10 analogs that bound lipid membranes better were also more active at the GPR54 receptor.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableLipid membrane binding versus agonist activity of analogs
    Study

    n: not reported in source

    membrane-mimetic medium
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We found that there is a close correlation between lipid membrane binding and agonist activity.
    1 context sentence
    Summary · context
    Here, we performed a series of structural analyses using alanine-scanning analogs of kisspeptin-10 in membrane-mimetic medium.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Activity measurement

    In membrane-mimetic medium, the F10A and non-amidated kisspeptin‑10 analogs showed little or no GPR54 agonist activity.

    In plain wordsIn lab tests, two changed kisspeptin‑10 analogs had little or no activity at the GPR54 receptor.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableGPR54 agonist activity of F10A and non-amidated analogs
    Study

    n: not reported in source

    membrane-mimetic medium
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    For instance, the F10A and non-amidated (NH2-->OH) analogs showed little or no GPR54-agonist activity and elicited no blue shift in tryptophan fluorescence.
    1 context sentence
    Summary · context
    Here, we performed a series of structural analyses using alanine-scanning analogs of kisspeptin-10 in membrane-mimetic medium.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Mechanism

    In membrane-mimetic medium, the F10A and non-amidated analogs elicited no blue shift in tryptophan fluorescence.

    In plain wordsIn lab tests, two changed kisspeptin‑10 analogs did not show the fluorescence shift linked to membrane binding.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTryptophan fluorescence blue shift of F10A and non-amidated analogs
    Study

    n: not reported in source

    membrane-mimetic medium
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    For instance, the F10A and non-amidated (NH2-->OH) analogs showed little or no GPR54-agonist activity and elicited no blue shift in tryptophan fluorescence.
    1 context sentence
    Summary · context
    Here, we performed a series of structural analyses using alanine-scanning analogs of kisspeptin-10 in membrane-mimetic medium.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  4. 04LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Other

    By NMR in DPC micelles, a kisspeptin‑10 analog contained several tight turn structures from Trp3 to Phe10 and no helical conformation.

    In plain wordsIn lab tests, a kisspeptin‑10 analog formed several tight turns in micelles but no helix.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableStructure of a kisspeptin-10 analog in DPC micelles
    Study

    n: not reported in source

    membrane-mimetic medium
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    NMR analysis of kisspeptin-10 analog in DPC micelles revealed it to contain several tight turn structures, encompassing residues Trp3 to Phe10, but no helical conformation like that seen previously with SDS micelles.
    1 context sentence
    Summary · context
    Here, we performed a series of structural analyses using alanine-scanning analogs of kisspeptin-10 in membrane-mimetic medium.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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