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Study · Animal study (in vivo) · rat · 2009

4 results

Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats.

Aagaard NK, Grøfte T, Greisen J, Malmlöf K, Johansen PB, Grønbaek H, Ørskov H, Tygstrup N, Vilstrup H

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society23 Feb 2009Cited by 2 (Europe PMC)

PMID19231263 (opens in a new tab)DOI10.1016/j.ghir.2009.01.001 (opens in a new tab)PepBankPUB-19231263
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In prednisolone-treated rats, ipamorelin reduced the hepatic capacity of urea-N synthesis.

    In plain wordsIn rats given prednisolone, ipamorelin reduced the liver's capacity to make urea.

    Peptide
    Ipamorelin
    Outcome
    DecreaseHepatic capacity of urea-N synthesis (CUNS)
    Study

    ratn: not reported in source

    Comparator
    Prednisolone-treated rats without ipamorelin
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    0.5 mg x kg(-1) x day(-1) · seven daysAs given in this study (rat).

    Measurements

    CUNS reduction
    20%
    ipamorelin with prednisolone

    Source sentences

    Summary
    In prednisolone treated rats Ipamorelin reduced CUNS by 20% (p<0.05), decreased the expression of urea cycle enzymes, neutralised N-balance, and normalized or improved organ N-contents.
    2 context sentences
    Summary · context
    Five groups of rats were included: (1) free-fed controls (2) pair-fed controls (3) prednisolone (delcortol, 4 mg x kg(-1) x day(-1)) (4) prednisolone and GH (1 mg x kg(-1) x day(-1)) (5) prednisolone and Ipamorelin (0.5 mg x kg(-1) x day(-1)).
    Summary · context
    After seven days the hepatic capacity of urea-N synthesis (CUNS) was determined in parallel with measurements of liver mRNA levels of urea cycle enzymes, whole-body N-balance, and N-contents of various organs.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In prednisolone-treated rats, ipamorelin decreased the expression of urea cycle enzymes.

    In plain wordsIn rats given prednisolone, ipamorelin lowered the expression of urea cycle enzyme genes in the liver.

    Peptide
    Ipamorelin
    Outcome
    DecreaseUrea cycle enzyme expression
    Study

    ratn: not reported in source

    Comparator
    Prednisolone-treated rats without ipamorelin
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    0.5 mg x kg(-1) x day(-1) · seven daysAs given in this study (rat).

    Source sentences

    Summary
    In prednisolone treated rats Ipamorelin reduced CUNS by 20% (p<0.05), decreased the expression of urea cycle enzymes, neutralised N-balance, and normalized or improved organ N-contents.
    2 context sentences
    Summary · context
    Five groups of rats were included: (1) free-fed controls (2) pair-fed controls (3) prednisolone (delcortol, 4 mg x kg(-1) x day(-1)) (4) prednisolone and GH (1 mg x kg(-1) x day(-1)) (5) prednisolone and Ipamorelin (0.5 mg x kg(-1) x day(-1)).
    Summary · context
    After seven days the hepatic capacity of urea-N synthesis (CUNS) was determined in parallel with measurements of liver mRNA levels of urea cycle enzymes, whole-body N-balance, and N-contents of various organs.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In prednisolone-treated rats, ipamorelin counteracted the prednisolone-induced fall in nitrogen balance.

    In plain wordsIn rats given prednisolone, ipamorelin offset the loss of body nitrogen caused by prednisolone.

    Peptide
    Ipamorelin
    Outcome
    IncreaseWhole-body nitrogen balance
    Study

    ratn: not reported in source

    Comparator
    Prednisolone-treated rats without ipamorelin
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    0.5 mg x kg(-1) x day(-1) · seven daysAs given in this study (rat).

    Source sentences

    Summary
    In prednisolone treated rats Ipamorelin reduced CUNS by 20% (p<0.05), decreased the expression of urea cycle enzymes, neutralised N-balance, and normalized or improved organ N-contents.
    2 context sentences
    Summary · context
    Five groups of rats were included: (1) free-fed controls (2) pair-fed controls (3) prednisolone (delcortol, 4 mg x kg(-1) x day(-1)) (4) prednisolone and GH (1 mg x kg(-1) x day(-1)) (5) prednisolone and Ipamorelin (0.5 mg x kg(-1) x day(-1)).
    Summary · context
    After seven days the hepatic capacity of urea-N synthesis (CUNS) was determined in parallel with measurements of liver mRNA levels of urea cycle enzymes, whole-body N-balance, and N-contents of various organs.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In prednisolone-treated rats, ipamorelin normalized or improved organ nitrogen contents.

    In plain wordsIn rats given prednisolone, ipamorelin restored or improved the nitrogen content of organs.

    Peptide
    Ipamorelin
    Outcome
    IncreaseOrgan nitrogen contents
    Study

    ratn: not reported in source

    Comparator
    Prednisolone-treated rats without ipamorelin
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    0.5 mg x kg(-1) x day(-1) · seven daysAs given in this study (rat).

    Source sentences

    Summary
    In prednisolone treated rats Ipamorelin reduced CUNS by 20% (p<0.05), decreased the expression of urea cycle enzymes, neutralised N-balance, and normalized or improved organ N-contents.
    2 context sentences
    Summary · context
    Five groups of rats were included: (1) free-fed controls (2) pair-fed controls (3) prednisolone (delcortol, 4 mg x kg(-1) x day(-1)) (4) prednisolone and GH (1 mg x kg(-1) x day(-1)) (5) prednisolone and Ipamorelin (0.5 mg x kg(-1) x day(-1)).
    Summary · context
    After seven days the hepatic capacity of urea-N synthesis (CUNS) was determined in parallel with measurements of liver mRNA levels of urea cycle enzymes, whole-body N-balance, and N-contents of various organs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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