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Study · Animal study (in vivo) · rat · 2009

2 results

Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system.

Pinilla L, Castellano JM, Romero M, Tena-Sempere M, Gaytán F, Aguilar E

Endocrinology19 Feb 2009Cited by 14 (Europe PMC)

PMID19228890 (opens in a new tab)DOI10.1210/en.2008-1381 (opens in a new tab)PepBankPUB-19228890
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In spontaneously hypertensive rats with delayed puberty, the in vivo gonadotropin response to systemic kisspeptin‑10 was fully preserved.

    In plain wordsIn rats with delayed puberty, the hormone response to kisspeptin‑10 was fully preserved.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGonadotropin response to systemic kisspeptin-10
    Study

    ratn: not reported in source

    spontaneously hypertensive (SH) rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · systemicAs given in this study (rat).

    Source sentences

    Summary
    Likewise, in vivo gonadotropin responses to ovariectomy and systemic kisspeptin-10 or GnRH administration, as well as in vitro gonadotropin responses to GnRH, were fully preserved in SH rats.
    1 context sentence
    Summary · context
    We analyze herein in female SH rats: 1) possible alterations in the expression and function of KiSS-1/GPR54 and GnRH/GnRH-receptor systems, 2) the integrity of feedback mechanisms governing the hypothalamic-pituitary-ovarian axis, and 3) the control of ovarian function by gonadotropins.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In spontaneously hypertensive rats with delayed puberty, no significant decrease in hypothalamic KiSS-1 mRNA was detected.

    In plain wordsIn rats with delayed puberty, the body's own KiSS-1 messenger RNA in the brain was not significantly lower.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeHypothalamic KiSS-1 mRNA
    Study

    ratn: not reported in source

    spontaneously hypertensive (SH) rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Our data demonstrate that, despite overtly delayed puberty, no significant decrease in hypothalamic KiSS-1, GPR54, or GnRH mRNA levels was detected in this strain.
    1 context sentence
    Summary · context
    We analyze herein in female SH rats: 1) possible alterations in the expression and function of KiSS-1/GPR54 and GnRH/GnRH-receptor systems, 2) the integrity of feedback mechanisms governing the hypothalamic-pituitary-ovarian axis, and 3) the control of ovarian function by gonadotropins.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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