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Study · Animal study (in vivo) · rat · 2009

5 results

Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms.

Thompson EL, Amber V, Stamp GW, Patterson M, Curtis AE, Cooke JH, Appleby GF, Dhillo WS, Ghatei MA, Bloom SR, Murphy KG

British journal of pharmacology1 Feb 2009Cited by 34 (Europe PMC)

PMID19226253 (opens in a new tab)PMCIDPMC2697701 (opens in a new tab)DOI10.1111/j.1476-5381.2008.00061.x (opens in a new tab)PepBankPUB-19226253
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In male rats, continuous subcutaneous kisspeptin‑54 caused testicular degeneration after only 12 hours.

    In plain wordsIn male rats, continuous kisspeptin‑54 under the skin damaged the testes within 12 hours.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseTesticular degeneration with continuous subcutaneous kisspeptin-54
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol.day(-1) · subcutaneous · 12 hAs given in this study (rat).

    Source sentences

    Summary
    Continuous subcutaneous administration of kisspeptin-54 caused testicular degeneration after only 12 h, when gonadotrophins were still markedly raised, suggesting that the degeneration is independent of the desensitization of the HPG axis to kisspeptin-54.
    1 context sentence
    Summary · context
    Kisspeptin-54 (50 nmol.day(-1)) was continuously administered subcutaneously (6 h to 3 days) to male Wistar rats and reproductive hormones and testicular histology analysed.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats given continuous subcutaneous kisspeptin‑54, gonadotrophins were still markedly raised when testicular degeneration appeared at 12 hours.

    In plain wordsIn male rats, hormones that drive the testes were still high when kisspeptin‑54 damaged the testes.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseGonadotrophin levels at onset of testicular degeneration
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 nmol.day(-1) · subcutaneous · 12 hAs given in this study (rat).

    Source sentences

    Summary
    Continuous subcutaneous administration of kisspeptin-54 caused testicular degeneration after only 12 h, when gonadotrophins were still markedly raised
    1 context sentence
    Summary · context
    Kisspeptin-54 (50 nmol.day(-1)) was continuously administered subcutaneously (6 h to 3 days) to male Wistar rats and reproductive hormones and testicular histology analysed.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In male rats, a single subcutaneous kisspeptin‑54 injection caused dose-dependent testicular degeneration.

    In plain wordsIn male rats, one kisspeptin‑54 injection under the skin damaged the testes, and more peptide caused more damage.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseTesticular degeneration after a single subcutaneous injection
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.5, 5 or 50 nmol · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, a single subcutaneous injection of kisspeptin-54 caused dose-dependent testicular degeneration.
    1 context sentence
    Summary · context
    We also investigated the effects of a single subcutaneous injection of 0.5, 5 or 50 nmol kisspeptin-54.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In male rats, a single intracerebroventricular kisspeptin‑54 injection caused testicular degeneration.

    In plain wordsIn male rats, kisspeptin‑54 injected into the brain also damaged the testes.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseTesticular degeneration after intracerebroventricular kisspeptin-54
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    a single i.c.v. injection of kisspeptin-54 caused testicular degeneration
    1 context sentence
    Summary · context
    In order to determine whether the testicular degeneration observed is peripherally or centrally mediated, we investigated effects of i.c.v. injections of 5 nmol kisspeptin-54 and pre-administered a GnRH-receptor antagonist (cetrorelix) to rats peripherally treated with kisspeptin-54.

Studies that did not test the peptide alone1

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

  1. 05AnimalNot a test of Kisspeptin-54 (metastin) aloneAnimal study (in vivo)Mechanism

    In male rats, pretreatment with the GnRH-receptor antagonist cetrorelix blocked the testicular degeneration caused by peripheral kisspeptin‑54.

    In plain wordsIn male rats, a drug that blocks GnRH receptors stopped the testis damage caused by kisspeptin‑54.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseCetrorelix pretreatment and kisspeptin-induced testicular degeneration
    Study

    ratn: not reported in source

    Male Wistar rats
    Comparator
    Kisspeptin-54 without cetrorelix
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Pretreatment with cetrorelix blocked kisspeptin-induced testicular degeneration
    1 context sentence
    Summary · context
    In order to determine whether the testicular degeneration observed is peripherally or centrally mediated, we investigated effects of i.c.v. injections of 5 nmol kisspeptin-54 and pre-administered a GnRH-receptor antagonist (cetrorelix) to rats peripherally treated with kisspeptin-54.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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