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Study · Not a test of the peptide alone · 2009

4 results

KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis.

Navenot JM, Fujii N, Peiper SC

Molecular pharmacology6 Feb 2009Cited by 33 (Europe PMC)

PMID19201817 (opens in a new tab)DOI10.1124/mol.108.054270 (opens in a new tab)PepBankPUB-19201817
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In cell lines, activation of GPR54 by the KiSS1 gene product abolished the activation of Akt by the epidermal growth factor and insulin receptors.

    In plain wordsIn cells, activating the kisspeptin receptor blocked Akt signaling from growth factor and insulin receptors. The activating compound is not named.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseAkt activation by EGF and insulin receptors
    Study

    n: not reported in source

    epithelial and lymphoid cell lines
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Title
    KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis.
    1 context sentence
    Summary · context
    We demonstrate here that activation of GPR54 can also abolish the activation of Akt by the tyrosine kinase receptors for epidermal growth factor and insulin.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Efficacy outcome

    In epithelial and lymphoid cell lines, GPR54 signaling was sufficient to trigger apoptosis.

    In plain wordsIn cells, kisspeptin receptor signaling was enough to trigger cell death in epithelial and lymphoid cell lines.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseApoptosis in epithelial and lymphoid cell lines
    Study

    n: not reported in source

    epithelial and lymphoid cell lines
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Title
    KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis.
    1 context sentence
    Summary · context
    The signaling of GPR54 was sufficient to trigger apoptosis in epithelial and lymphoid cell lines.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In cell lines, GPR54-triggered apoptosis depended largely on ERK activation rather than on inhibition of Akt.

    In plain wordsIn cells, cell death after kisspeptin receptor activation depended mostly on ERK, not on Akt inhibition.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableERK dependence of apoptosis
    Study

    n: not reported in source

    epithelial and lymphoid cell lines
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Title
    KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis.
    1 context sentence
    Summary · context
    Surprisingly, this phenomenon depended largely on the activation of extracellular signal-regulated kinase (ERK) rather than the inhibition of Akt.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  4. 04LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In a lymphoid cell line, GPR54 activation resulted in ERK-dependent expression of tumor necrosis factor-alpha and FasL.

    In plain wordsIn cells, kisspeptin receptor activation raised the signals TNF-alpha and FasL, depending on ERK.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTNF-alpha and FasL expression
    Study

    n: not reported in source

    epithelial and lymphoid cell lines
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Title
    KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis.
    1 context sentence
    Summary · context
    Activation of GPR54 resulted in the ERK-dependent expression of tumor necrosis factor-alpha and FasL in a lymphoid cell line, the latter being the main trigger of apoptosis.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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