In mouse GnRH neurons, submaximal concentrations of kisspeptin‑10 abrogated the GABA(B) receptor-mediated outward current in both estradiol and vehicle groups.
In plain wordsIn mouse nerve cells, kisspeptin‑10 blocked the current that a GABA(B) receptor drug caused, in both estradiol-treated and vehicle-treated cells.
- Peptide
- Kisspeptin-10
- Outcome
- DecreaseBaclofen-induced outward current with kisspeptin-10
- Study
mousen: not reported in source
whole-cell recordings of EGFP-GnRH neurons- Outcome group
- Receptor activity and mechanism · Endocrine and hormones
- Studied dose
- submaximal concentrationsAs given in this study (mouse).
Source sentences
However, the outward current (and membrane hyperpolarization) was abrogated by submaximal concentrations of the G protein-coupled receptor 54 (GPR54) agonist kisspeptin-10 in both groups, indicating that G alpha(q)-coupled (GPR54) can desensitize the GABA(B) receptor-mediated response.
1 context sentence(design, population, supporting numbers)
Using whole-cell recordings from mouse enhanced green fluorescent protein-GnRH neurons, we found that the GABA(B) receptor agonist baclofen hyperpolarized GnRH neurons through activation of an inwardly rectifying K(+) current in a concentration-dependent manner.