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Study · Animal study (in vivo) · rat and sea bass · 2009

3 results

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals.

Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena-Sempere M, Gómez A

Molecular and cellular endocrinology25 Nov 2008Cited by 175 (Europe PMC)

PMID19084576 (opens in a new tab)DOI10.1016/j.mce.2008.11.017 (opens in a new tab)PepBankPUB-19084576
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sea bass, the KiSS-1 peptide (identical to rodent kisspeptin‑10) was significantly less potent than the KiSS-2 decapeptide at inducing LH and FSH secretion.

    In plain wordsIn sea bass, the KiSS-1 peptide was less potent than the KiSS-2 peptide at triggering release of LH and FSH hormones.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableLH and FSH secretion potency versus KiSS-2 decapeptide in sea bass
    Study

    sea bassn: not reported in source

    Comparator
    KiSS-2 decapeptide
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Comparative functional studies demonstrated that KiSS-2 decapeptide was significantly more potent than KiSS-1 peptide in inducing LH and FSH secretion in sea bass.
    1 context sentence
    Summary · context
    While KiSS-1 encodes a peptide identical to rodent kisspeptin-10, the predicted KiSS-2 decapeptide diverges at 4 amino acids (FNFNPFGLRF).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the KiSS-1 peptide was maximally effective at eliciting LH secretion, whereas the KiSS-2 decapeptide elicited it only weakly.

    In plain wordsIn rats, the KiSS-1 peptide raised LH very effectively, while the KiSS-2 peptide had only a weak effect.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH secretion in rats versus KiSS-2 decapeptide
    Study

    ratn: not reported in source

    Comparator
    KiSS-2 decapeptide
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, KiSS-2 decapeptide only weakly elicited LH secretion in rats, whereas KiSS-1 peptide was maximally effective.
    1 context sentence
    Summary · context
    While KiSS-1 encodes a peptide identical to rodent kisspeptin-10, the predicted KiSS-2 decapeptide diverges at 4 amino acids (FNFNPFGLRF).

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In sea bass, medaka and zebrafish, KiSS-1 mRNA was present in brain and gonads.

    In plain wordsIn sea bass, medaka and zebrafish, the body's own KiSS-1 messenger RNA, from which kisspeptin is made, was found in brain and gonads.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKiSS-1 mRNA presence in brain and gonads
    Study

    sea bass, medaka and zebrafishn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    KiSS-1 and KiSS-2 mRNAs are present in brain and gonads of sea bass, medaka and zebrafish.
    1 context sentence
    Summary · context
    While KiSS-1 encodes a peptide identical to rodent kisspeptin-10, the predicted KiSS-2 decapeptide diverges at 4 amino acids (FNFNPFGLRF).

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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