[Expression of laminin 5 in rat skin wounds regulated by recombinant thymosin beta4].

Li Y, Wang G, Yu H, Yang X, Xu S, Nie L, Che Y

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery1 Nov 2008Cited by 1 (Europe PMC)

PMID19068595PepBankPUB-19068595

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with skin wounds, wound healing rates 4 days after operation were 37.99%, 42.00% and 39.58% with low, medium and high dose thymosin beta‑4 and 28.16% in controls; significance is not stated.
In plain wordsIn rats with skin wounds, healing rates at 4 days were numerically higher with thymosin beta‑4 than control, but the abstract gives no significance.
Peptide
Thymosin beta-4 (human)
Outcome
Direction not reportedWound healing rate at day 4
Study
ratn = 60
full thickness 8 mm punch skin wounds in adult male rats
Comparator
Phosphate buffered saline (control)
Outcome group
Wound healing · Skin and wound
Studied dose
2, 6 and 18 microg every 12 hours · topical · 4 daysAs given in this study (rat).
Measurements
Wound healing rate
28.16%
control, day 4
Wound healing rate
37.99%
low dose, day 4
Wound healing rate
42%
medium dose, day 4
Wound healing rate
39.58%
high dose, day 4
Source sentences
Summary
28.16% +/- 13.76%, 37.99% +/- 13.05%, 42.00% +/- 9.56% and 39.58% +/- 12.74% respectively 4 days after operation
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859504
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with skin wounds, wound healing rates 7 days after operation were 64.15%, 77.39% and 69.78% with low, medium and high dose thymosin beta‑4 and 59.08% in controls; significance is not stated.
In plain wordsIn rats with skin wounds, healing rates at 7 days were numerically higher with thymosin beta‑4 than control, but the abstract gives no significance.
Peptide
Thymosin beta-4 (human)
Outcome
Direction not reportedWound healing rate at day 7
Study
ratn = 60
full thickness 8 mm punch skin wounds in adult male rats
Comparator
Phosphate buffered saline (control)
Outcome group
Wound healing · Skin and wound
Studied dose
2, 6 and 18 microg every 12 hours · topical · 7 daysAs given in this study (rat).
Measurements
Wound healing rate
59.08%
control, day 7
Wound healing rate
64.15%
low dose, day 7
Wound healing rate
77.39%
medium dose, day 7
Wound healing rate
69.78%
high dose, day 7
Source sentences
Summary
59.08% +/- 19.02%, 64.15% +/- 17.92%, 77.39% +/- 8.45% and 69.78% +/- 8.45% respectively 7 days after operation
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859505
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with skin wounds, topical thymosin beta‑4 at the low dose increased the wound healing rate versus control 2 days after operation.
In plain wordsIn rats with skin wounds, a low dose of thymosin beta‑4 on the skin raised the wound healing rate more than control at 2 days.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseWound healing rate at day 2, low dose
Study
ratn = 30
full thickness 8 mm punch skin wounds in adult male rats
Comparator
Phosphate buffered saline (control)
Outcome group
Wound healing · Skin and wound
Studied dose
2 microg every 12 hours · topical · 2 daysAs given in this study (rat).
Measurements
Wound healing rate
29.01%
low dose, day 2
Wound healing rate
7.67%
control, day 2
Source sentences
Summary
In the control group, low dose group, medium dose group and high dose group, the wound healing rate were 7.67% +/- 5.46%, 29.01% +/- 7.43%, 26.54% +/- 11.49% and 10.39% +/- 3.96% respectively 2 days after operation
3 context sentences(design, population, supporting numbers)
Summary · context
At 2 days after operation, significant differences were notified in healing rats between 3 sub-experimental groups and the control group (P < 0.05).
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859501
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with skin wounds, topical thymosin beta‑4 at the medium dose increased the wound healing rate versus control 2 days after operation.
In plain wordsIn rats with skin wounds, a medium dose of thymosin beta‑4 on the skin raised the wound healing rate more than control at 2 days.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseWound healing rate at day 2, medium dose
Study
ratn = 30
full thickness 8 mm punch skin wounds in adult male rats
Comparator
Phosphate buffered saline (control)
Outcome group
Wound healing · Skin and wound
Studied dose
6 microg every 12 hours · topical · 2 daysAs given in this study (rat).
Measurements
Wound healing rate
26.54%
medium dose, day 2
Wound healing rate
7.67%
control, day 2
Source sentences
Summary
In the control group, low dose group, medium dose group and high dose group, the wound healing rate were 7.67% +/- 5.46%, 29.01% +/- 7.43%, 26.54% +/- 11.49% and 10.39% +/- 3.96% respectively 2 days after operation
3 context sentences(design, population, supporting numbers)
Summary · context
At 2 days after operation, significant differences were notified in healing rats between 3 sub-experimental groups and the control group (P < 0.05).
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859502
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with skin wounds, topical thymosin beta‑4 at the high dose increased the wound healing rate versus control 2 days after operation.
In plain wordsIn rats with skin wounds, a high dose of thymosin beta‑4 on the skin raised the wound healing rate more than control at 2 days.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseWound healing rate at day 2, high dose
Study
ratn = 30
full thickness 8 mm punch skin wounds in adult male rats
Comparator
Phosphate buffered saline (control)
Outcome group
Wound healing · Skin and wound
Studied dose
18 microg every 12 hours · topical · 2 daysAs given in this study (rat).
Measurements
Wound healing rate
10.39%
high dose, day 2
Wound healing rate
7.67%
control, day 2
Source sentences
Summary
In the control group, low dose group, medium dose group and high dose group, the wound healing rate were 7.67% +/- 5.46%, 29.01% +/- 7.43%, 26.54% +/- 11.49% and 10.39% +/- 3.96% respectively 2 days after operation
3 context sentences(design, population, supporting numbers)
Summary · context
At 2 days after operation, significant differences were notified in healing rats between 3 sub-experimental groups and the control group (P < 0.05).
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859503
06AnimalAnimal study (in vivo)Mechanism
In rats with skin wounds, the medium dose of thymosin beta‑4 was linked to less laminin 5 expression early, limited to the wound border and bottom.
In plain wordsIn rats with skin wounds, a medium dose of thymosin beta‑4 was linked to less laminin 5 early in healing.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseLaminin 5 expression at day 2, medium dose
Study
ratn: not reported in source
full thickness 8 mm punch skin wounds in adult male rats
Outcome group
Wound healing · Skin and wound
Studied dose
6 microg every 12 hours · topical · 2 daysAs given in this study (rat).
Source sentences
Summary
But in medium group there was fewer expression, only at the borderline and bottom of the wound, while the expression significantly increased 4 days after operation (P < 0.05) and there was a relative high expression 7 days after operation (P < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859506
07AnimalAnimal study (in vivo)Mechanism
In rats with skin wounds, laminin 5 expression with the medium dose of thymosin beta‑4 increased significantly 4 days after operation.
In plain wordsIn rats with skin wounds, laminin 5 rose at 4 days with a medium dose of thymosin beta‑4.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseLaminin 5 expression at day 4, medium dose
Study
ratn: not reported in source
full thickness 8 mm punch skin wounds in adult male rats
Outcome group
Wound healing · Skin and wound
Studied dose
6 microg every 12 hours · topical · 4 daysAs given in this study (rat).
Measurements
P value
< 0.05
medium dose, day 4
Source sentences
Summary
But in medium group there was fewer expression, only at the borderline and bottom of the wound, while the expression significantly increased 4 days after operation (P < 0.05) and there was a relative high expression 7 days after operation (P < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859507
08AnimalAnimal study (in vivo)Mechanism
In rats with skin wounds, laminin 5 expression with the medium dose of thymosin beta‑4 was relatively high 7 days after operation.
In plain wordsIn rats with skin wounds, laminin 5 was relatively high at 7 days with a medium dose of thymosin beta‑4.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseLaminin 5 expression at day 7, medium dose
Study
ratn: not reported in source
full thickness 8 mm punch skin wounds in adult male rats
Outcome group
Wound healing · Skin and wound
Studied dose
6 microg every 12 hours · topical · 7 daysAs given in this study (rat).
Measurements
P value
< 0.01
medium dose, day 7
Source sentences
Summary
But in medium group there was fewer expression, only at the borderline and bottom of the wound, while the expression significantly increased 4 days after operation (P < 0.05) and there was a relative high expression 7 days after operation (P < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty rats were randomized into the control group (n = 15) and the experimental group (n = 45), which was subdivided into low, medium and high dose groups (n = 15).
Summary · context
Tbeta4 was applied topically at 2, 6, 18 microg in 50 microL PBS for every 12 hours after model making in the experimental group.
Report a problemFND-1906859508

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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