Skip to content

Study · Animal study (in vivo) · rat · 2008

3 results

Somatostatin 2A receptor-expressing presympathetic neurons in the rostral ventrolateral medulla maintain blood pressure.

Burke PG, Li Q, Costin ML, McMullan S, Pilowsky PM, Goodchild AK

Hypertension (Dallas, Tex. : 1979)10 Nov 2008Cited by 43 (Europe PMC)

PMID19001189 (opens in a new tab)DOI10.1161/hypertensionaha.108.118224 (opens in a new tab)PepBankPUB-19001189
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, lanreotide microinjection caused dose-dependent sympathoinhibition that an sst2 antagonist blocked.

    In plain wordsIn rats under anesthesia, lanreotide reduced sympathetic activity with increasing doses, and an sst2 antagonist blocked this effect.

    Peptide
    Lanreotide
    Outcome
    DecreaseSympathetic activity
    Study

    ratn: not reported in source

    Anesthetized rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · bilateral microinjection into the rostral ventrolateral medullaAs given in this study (rat).

    Source sentences

    Summary
    Bilateral microinjection into the RVLM of either somatostatin or the receptor-selective agonist lanreotide evoked dramatic, dose-dependent sympathoinhibition, hypotension, and bradycardia that were blocked by the sst2 receptor antagonist BIM-23627 in anesthetized rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, lanreotide microinjection caused dose-dependent hypotension that an sst2 antagonist blocked.

    In plain wordsIn rats under anesthesia, lanreotide lowered blood pressure with increasing doses, and an sst2 antagonist blocked this effect.

    Peptide
    Lanreotide
    Outcome
    DecreaseBlood pressure
    Study

    ratn: not reported in source

    Anesthetized rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · bilateral microinjection into the rostral ventrolateral medullaAs given in this study (rat).

    Source sentences

    Summary
    Bilateral microinjection into the RVLM of either somatostatin or the receptor-selective agonist lanreotide evoked dramatic, dose-dependent sympathoinhibition, hypotension, and bradycardia that were blocked by the sst2 receptor antagonist BIM-23627 in anesthetized rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, lanreotide microinjection caused dose-dependent bradycardia that an sst2 antagonist blocked.

    In plain wordsIn rats under anesthesia, lanreotide slowed heart rate with increasing doses, and an sst2 antagonist blocked this effect.

    Peptide
    Lanreotide
    Outcome
    DecreaseHeart rate
    Study

    ratn: not reported in source

    Anesthetized rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · bilateral microinjection into the rostral ventrolateral medullaAs given in this study (rat).

    Source sentences

    Summary
    Bilateral microinjection into the RVLM of either somatostatin or the receptor-selective agonist lanreotide evoked dramatic, dose-dependent sympathoinhibition, hypotension, and bradycardia that were blocked by the sst2 receptor antagonist BIM-23627 in anesthetized rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.