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Study · Ex vivo tissue · mouse · 2009

5 results

Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons.

Constantin S, Caligioni CS, Stojilkovic S, Wray S

Endocrinology23 Oct 2008Cited by 88 (Europe PMC)

PMID18948403 (opens in a new tab)PMCIDPMC2654742 (opens in a new tab)DOI10.1210/en.2008-0979 (opens in a new tab)PepBankPUB-18948403
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In mouse GnRH-1 neurons, kisspeptin‑10 initiated intracellular calcium oscillations in quiescent cells.

    In plain wordsIn mouse nerve cells in a dish, kisspeptin‑10 started calcium oscillations in resting GnRH-1 cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCalcium oscillations in quiescent GnRH-1 cells
    Study

    mousen: not reported in source

    GnRH-1 neurons in mouse nasal explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Activation of native GPR54 by kisspeptin-10 initiated [Ca(2+)](i) oscillations in quiescent GnRH-1 cells
    1 context sentence
    Summary · context
    In the present study, we used GnRH-1 neurons maintained in mice nasal explants to examine the expression and signaling of GPR54.
  2. 02LabEx vivo tissueMechanism

    In mouse GnRH-1 neurons, kisspeptin‑10 increased the frequency of calcium spiking in oscillating cells.

    In plain wordsIn mouse nerve cells in a dish, kisspeptin‑10 made calcium spikes more frequent in already active GnRH-1 cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCalcium spiking frequency in oscillating cells
    Study

    mousen: not reported in source

    GnRH-1 neurons in mouse nasal explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased the frequency of calcium spiking in oscillating cells
    1 context sentence
    Summary · context
    In the present study, we used GnRH-1 neurons maintained in mice nasal explants to examine the expression and signaling of GPR54.
  3. 03LabEx vivo tissueMechanism

    In a subset of active mouse GnRH-1 neurons, kisspeptin‑10 summed individual calcium spikes into plateau-bursting signals.

    In plain wordsIn mouse nerve cells in a dish, kisspeptin‑10 turned calcium spikes into longer bursts in some active GnRH-1 cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlateau-bursting calcium signals
    Study

    mousen: not reported in source

    GnRH-1 neurons in mouse nasal explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    that led to summation of individual spikes into plateau-bursting type of calcium signals in a subset of active cells.
    1 context sentence
    Summary · context
    In the present study, we used GnRH-1 neurons maintained in mice nasal explants to examine the expression and signaling of GPR54.
  4. 04LabEx vivo tissueMechanism

    Receptor activation by kisspeptin‑10 acted through phospholipase C signaling, with inositol trisphosphate and protein kinase C contributing to the modulation of calcium oscillations.

    In plain wordsIn mouse nerve cells in a dish, kisspeptin‑10 changed calcium signals through the phospholipase C pathway, with two of its parts contributing.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableRole of phospholipase C pathway components
    Study

    mousen: not reported in source

    GnRH-1 neurons in mouse nasal explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These changes predominantly reflected the stimulatory effect of GPR54 activation on the plasma membrane oscillator activity via coupling of this receptor to phospholipase C signaling pathways. Both components of this pathway, inositol 1,3,4-trisphosphate and protein kinase C, contributed to the rece…
    1 context sentence
    Summary · context
    In the present study, we used GnRH-1 neurons maintained in mice nasal explants to examine the expression and signaling of GPR54.
  5. 05LabEx vivo tissueMechanism

    In mouse GnRH-1 neurons, TTX plus 2-aminoethyl diphenylborinate abolished the kisspeptin‑10-induced calcium elevation in almost all cells, while flufenamic acid was less effective.

    In plain wordsIn mouse nerve cells in a dish, two channel blockers together stopped the kisspeptin‑10 calcium rise in almost all cells.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin-10-induced calcium elevation with channel blockers
    Study

    mousen: not reported in source

    GnRH-1 neurons in mouse nasal explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TTX and 2-aminoethyl diphenylborinate together abolished agonist-induced elevation in [Ca(2+)](i) in almost all cells, whereas flufenamic acid was less effective.
    1 context sentence
    Summary · context
    In the present study, we used GnRH-1 neurons maintained in mice nasal explants to examine the expression and signaling of GPR54.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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