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Study · Animal study (in vivo) · mouse · 2008

5 results

Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice.

Kamei J, Ohsawa M, Miyata S, Tanaka S

European journal of pharmacology9 Oct 2008Cited by 25 (Europe PMC)

PMID18930724 (opens in a new tab)DOI10.1016/j.ejphar.2008.10.002 (opens in a new tab)PepBankPUB-18930724
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, L‑carnosine ameliorated abnormal sensory perception.

    In plain wordsIn diabetic mice, L‑carnosine improved abnormal sensory perception.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedAbnormal sensory perception
    Study

    mousen: not reported in source

    streptozotocin-induced diabetes
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, L-carnosine, but not zinc sulfate, ameliorated the abnormal sensory perception in diabetic mice.
    1 context sentence
    Summary · context
    Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc L-carnosine on the changes of nociceptive threshold in diabetic mice. Zinc L-carnosine (75-300 mg/kg, p.o.) was administered once…

Studies that did not test the peptide alone4

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 02AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In diabetic mice, zinc L‑carnosine ameliorated the shortened tail-flick latency in the early stage.

    In plain wordsIn diabetic mice, zinc L‑carnosine reduced early tail-flick latency shortening compared with no zinc L‑carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    IncreaseEarly-stage tail-flick latency
    Study

    mousen: not reported in source

    streptozotocin-induced diabetes
    Comparator
    diabetic mice without zinc L-carnosine
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    The shortened tail-flick latency in early stage of diabetic mice was ameliorated by treatment with zinc L-carnosine.
    2 context sentences
    Summary · context
    Diabetic mice showed shorter tail-flick latency at 1-4 weeks after streptozotocin treatment and longer tail-flick latency at 6-9 weeks after its treatment.
    Summary · context
    Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc L-carnosine on the changes of nociceptive threshold in diabetic mice. Zinc L-carnosine (75-300 mg/kg, p.o.) was administered once…

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 03AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In diabetic mice, zinc L‑carnosine slowed the onset of hypoalgesia.

    In plain wordsIn diabetic mice, zinc L‑carnosine delayed reduced pain sensitivity compared with no zinc L‑carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    DecreaseHypoalgesia development
    Study

    mousen: not reported in source

    streptozotocin-induced diabetes
    Comparator
    diabetic mice without zinc L-carnosine
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Moreover, zinc L-carnosine also slowed the onset of hypoalgesia in diabetic mice.
    1 context sentence
    Summary · context
    Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc L-carnosine on the changes of nociceptive threshold in diabetic mice. Zinc L-carnosine (75-300 mg/kg, p.o.) was administered once…

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 04AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In non-diabetic mice, zinc L‑carnosine did not affect tail-flick latency.

    In plain wordsIn non-diabetic mice, zinc L‑carnosine did not change tail-flick latency compared with no zinc L‑carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    No significant changeNormal tail-flick latency
    Study

    mousen: not reported in source

    non-diabetic mice
    Comparator
    non-diabetic mice without zinc L-carnosine
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Tail-flick latency in non-diabetic mice was not affected by the zinc L-carnosine treatment, indicating that zinc L-carnosine did not affect normal nociceptive transmission.
    1 context sentence
    Summary · context
    Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc L-carnosine on the changes of nociceptive threshold in diabetic mice. Zinc L-carnosine (75-300 mg/kg, p.o.) was administered once…

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  4. 05AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In diabetic mice, zinc L‑carnosine ameliorated abnormal sensory perception more strongly than L‑carnosine.

    In plain wordsIn diabetic mice, zinc L‑carnosine improved abnormal sensory perception more than L‑carnosine.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedAbnormal sensory perception with zinc complex versus native peptide
    Study

    mousen: not reported in source

    streptozotocin-induced diabetes
    Comparator
    L-carnosine
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Interestingly, the ameliorative effect of zinc l-carnosine on the abnormal sensory perception in diabetic mice is much stronger than that of L-carnosine.
    1 context sentence
    Summary · context
    Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc L-carnosine on the changes of nociceptive threshold in diabetic mice. Zinc L-carnosine (75-300 mg/kg, p.o.) was administered once…

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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