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Study · Animal study (in vivo) · rhesus monkey · 2008

4 results

Short-term fasting attenuates the response of the HPG axis to kisspeptin challenge in the adult male rhesus monkey (Macaca mulatta).

Wahab F, Aziz F, Irfan S, Zaman WU, Shahab M

Life sciences16 Sept 2008Cited by 30 (Europe PMC)

PMID18834893 (opens in a new tab)DOI10.1016/j.lfs.2008.09.001 (opens in a new tab)PepBankPUB-18834893
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, intravenous kisspeptin‑10 caused a robust stimulation of testosterone secretion in both fed and fasted animals.

    In plain wordsIn male rhesus monkeys, kisspeptin‑10 strongly raised testosterone release, both when fed and when fasted.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTestosterone secretion after kisspeptin-10
    Study

    rhesus monkeyn = 5

    adult male rhesus monkeys, in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 microg · intravenous bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    KP10 administration caused a robust stimulation of T secretion in both fed and fasted monkeys.
    1 context sentence
    Summary · context
    Five intact adult male rhesus monkeys habituated to chair-restraint, received intravenous boli of human kisspeptin-10 (KP10, 50 microg), hCG (50 IU), and vehicle (1 ml) in both fed and 48-h fasting conditions.

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, 48-h fasting reduced the mean testosterone concentration after a kisspeptin‑10 bolus compared with the fed state.

    In plain wordsIn male rhesus monkeys, fasting reduced the testosterone rise after kisspeptin‑10 compared with the fed state.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseMean testosterone after kisspeptin-10 in fasted monkeys
    Study

    rhesus monkeyn = 5

    adult male rhesus monkeys, in vivo
    Comparator
    Fed condition
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    mean T concentration and T AUC after KP10 administration were significantly (P<0.01-0.005) reduced in fasted monkeys
    1 context sentence
    Summary · context
    Five intact adult male rhesus monkeys habituated to chair-restraint, received intravenous boli of human kisspeptin-10 (KP10, 50 microg), hCG (50 IU), and vehicle (1 ml) in both fed and 48-h fasting conditions.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, 48-h fasting reduced the testosterone area under the curve after a kisspeptin‑10 bolus compared with the fed state.

    In plain wordsIn male rhesus monkeys, fasting reduced total testosterone release after kisspeptin‑10 compared with the fed state.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTestosterone AUC after kisspeptin-10 in fasted monkeys
    Study

    rhesus monkeyn = 5

    adult male rhesus monkeys, in vivo
    Comparator
    Fed condition
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    mean T concentration and T AUC after KP10 administration were significantly (P<0.01-0.005) reduced in fasted monkeys
    1 context sentence
    Summary · context
    Five intact adult male rhesus monkeys habituated to chair-restraint, received intravenous boli of human kisspeptin-10 (KP10, 50 microg), hCG (50 IU), and vehicle (1 ml) in both fed and 48-h fasting conditions.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, 48-h fasting delayed the first significant increase in testosterone after a kisspeptin‑10 bolus compared with the fed state.

    In plain wordsIn male rhesus monkeys, fasting delayed the first testosterone rise after kisspeptin‑10 compared with the fed state.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTime to first significant testosterone increase after kisspeptin-10
    Study

    rhesus monkeyn = 5

    adult male rhesus monkeys, in vivo
    Comparator
    Fed condition
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Likewise, the time of the first significant increase in post-KP10 T levels was also significantly (P<0.01) delayed.
    1 context sentence
    Summary · context
    Five intact adult male rhesus monkeys habituated to chair-restraint, received intravenous boli of human kisspeptin-10 (KP10, 50 microg), hCG (50 IU), and vehicle (1 ml) in both fed and 48-h fasting conditions.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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